Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Max, N; Harbaum, L; Pollheimer, MJ; Lindtner, RA; Kornprat, P; Langner, C.
Tumour budding with and without admixed inflammation: two different sides of the same coin?
Br J Cancer. 2016; 114(4):368-371
Doi: 10.1038/bjc.2015.454
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Kornprat Peter
- Pollheimer Marion
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- Abstract:
- Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets. We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses. Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect. Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cohort Studies -
- Colorectal Neoplasms - pathology
- Female -
- Humans -
- Inflammation - pathology
- Male -
- Neoplasm Invasiveness -
- Prognosis -
- Find related publications in this database (Keywords)
- colorectal cancer
- tumour budding
- inflammation
- prognosis
- survival
- multivariate logistic regression
- epithelial-mesenchymal transition