Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Koestenberger, M; Burmas, A; Ravekes, W; Avian, A; Gamillscheg, A; Grangl, G; Grillitsch, M; Hansmann, G.
Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension.
Pediatr Cardiol. 2016; 37(4):686-695
Doi: 10.1007/s00246-015-1332-0
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- Führende Autor*innen der Med Uni Graz
- Koestenberger Martin
- Co-Autor*innen der Med Uni Graz
- Aschenbrenner Marlene
- Avian Alexander
- Burmas Ante
- Gamillscheg Andreas
- Grangl Gernot
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- Abstract:
- Right atrial (RA) size may become a very useful, easily obtainable, echocardiographic variable in patients with congenital heart disease (CHD) with right-heart dysfunction; however, according studies in children are lacking. We investigated growth-related changes of RA dimensions in healthy children. Moreover, we determined the predictive value of RA variables in both children with secundum atrial septal defect (ASD) and children with pulmonary hypertension (PH) secondary to CHD (PH-CHD). This is a prospective study in 516 healthy children, in 80 children with a secundum ASD (>7 mm superior-inferior dimension), and in 42 children with PH-CHD. We determined three RA variables, i.e., end-systolic major-axis length, end-systolic minor-axis length, and end-systolic area, stratified by age, body weight, length, and surface area. RA end-systolic length and area z scores were increased in children with ASD and PH-CHD when compared to those variables in the healthy control population. Using the Youden Index to determine the best cutoff scores in sex- and age-specific RA dimensions, we observed a sensitivity and specificity up to 94 and 91 %, respectively, in ASD children and 98 and 94 %, respectively, in PH-CHD children. We provide normal values (z scores -2 to +2) for RA size and area in a representative, large pediatric cohort. Enlarged RA variables with scores >+2 were predictive of secundum ASD and PH-CHD. Two-dimensional determination of RA size can identify enlarged RAs in the setting of high volume load (ASD) or pressure load (PH-CHD).
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Cardiomegaly - diagnostic imaging
- Case-Control Studies -
- Child -
- Child, Preschool -
- Echocardiography -
- Female -
- Heart Atria - diagnostic imaging
- Heart Septal Defects, Atrial - complications
- Heart Septal Defects, Atrial - diagnostic imaging
- Humans -
- Hypertension, Pulmonary - diagnostic imaging
- Infant -
- Infant, Newborn -
- Male -
- Prospective Studies -
- ROC Curve -
- Reference Values -
- Regression Analysis -
- Find related publications in this database (Keywords)
- Atrial septal defect
- Children
- End-systolic length and area
- Pulmonary hypertension secondary to congenital heart disease
- Right atrial enlargement