Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Planchette, C; Pichler, H; Wimmer-Teubenbacher, M; Gruber, M; Gruber-Woelfler, H; Mohr, S; Tetyczka, C; Hsiao, WK; Paudel, A; Roblegg, E; Khinast, J.
Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure.
Int J Pharm. 2016; 509(1-2):518-527
Doi: 10.1016/j.ijpharm.2015.10.054
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Gruber Michael
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- Abstract:
- We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a non-contact printing system that incorporates both piezoelectric- and solenoid valve-based inkjet printing technologies, to deliver both active and inactive pharmaceutical materials onto medical-graded orodispersible films. By using two complimentary inkjet technologies, we were able to dispense an extensive range of fluids, from aqueous drug solutions to viscous polymer coating materials. Essentially, we demonstrate printing of a wide range of formulations for patient-ready, orodispersible drug dosage forms, without the risk of drug degradation by ink heating and of substrate damages (by contact printing). In addition, our printing process has been optimized to ensure that the drug doses can be loaded onto the orally dissolvable films without introducing defects, such as holes or tears, while retaining a smooth surface texture that promotes patient adherence and allows for uniform post-coatings. Results show that our platform technology can address key issues in manufacturing orodispersible drug dosage forms and bring us closer to delivering personalized and precision medicine to targeted patient populations. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Chemistry, Pharmaceutical - methods
- Dosage Forms -
- Drug Delivery Systems - methods
- Excipients - chemistry
- Pharmaceutical Preparations - chemistry
- Pharmaceutical Solutions - chemistry
- Precision Medicine - methods
- Printing - methods
- Surface Properties -
- Technology, Pharmaceutical - methods
- Viscosity -
- Find related publications in this database (Keywords)
- Printed medicine
- Personalized medicine
- Precision medicine
- Orodispersible dosage form
- Ink formulation
- Nanosuspension
- Coating
- Doses combination
- Pediatric
- Geriatric
- Patient adherence
- Inkjet printing