Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Parichatikanond, W; Pinthong, D; Mangmool, S.
Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin.
Planta Med. 2012; 78(15):1626-1632
Doi: 10.1055/s-0032-1315198
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Parichatikanond Warisara
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- Abstract:
- Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production. Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production. However, delphinidin, cyanin, and quercetin did not act as the angiotensin II type 1 receptor antagonist and did not play roles in the regulation of its internalization. The direct inhibition of components of the renin-angiotensin system advances our understanding of the antihypertensive effects of these compounds. Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensin-Converting Enzyme Inhibitors - pharmacology
- Anthocyanins - pharmacology
- Antihypertensive Agents - pharmacology
- Blood Pressure - drug effects
- Glucosides - pharmacology
- HEK293 Cells -
- Humans -
- Hypertension - drug therapy Hypertension - physiopathology
- Quercetin - pharmacology
- Renin - antagonists & inhibitors Renin - genetics
- Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology
- Signal Transduction - drug effects
- Find related publications in this database (Keywords)
- angiotensin-converting enzyme
- cyanin
- delphinidin
- quercetin
- renin
- renin-angiotensin system