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Schimpl, G; Höllwarth, ME; Fotter, R; Becker, H.
Late Intestinal Strictures Following Successful Treatment of Necrotizing Enterocolitis
ACTA PAEDIAT 1994 83: 80-83. Doi: 10.1111/j.1651-2227.1994.tb13251.x
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Leading authors Med Uni Graz: Schimpl Guenther
Co-authors Med Uni Graz: Fotter Richard; Höllwarth Michael
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Abstract:: Between 1975 and 1992, in 16 infants (14%) out of 113 neonates with previous necrotizing enterocolitis (NEC) a total of 25 intestinal strictures had to be treated. Four (16%) were found in the ileum and 21 (84%) in the colon, and in 50% multiple strictures were present. In these 16 patients initial treatment for acute NEC included conservative treatment in 5, primary resection and enterostomies in 6 and proximal diverting enterostomies in 5. Therefore, the incidence of late strictures was 11% after conservative therapy, 11% after primary resection and 55% after primary proximal diverting enterostomies. An average of 49 days elapses between the recovery from NEC and the diagnosis of late strictures in conservatively treated patients. After initial surgical treatment, late strictures were detected on contrast studies on an average of 80 days. In pathologic specimens, marked fibrosis in the submucosa was consistently present in all strictures, whereas inflammatory changes in the mucosa, disruption or hypertrophy of the muscle layers or absence of ganglion cells were seen less frequently. All strictures were resected and primary end-to-end anastomosis was performed. But despite the development of late intestinal strictures, bowel preservation was improved after initial restrictive surgical therapy and aggressive medical treatment.
Find related publications in this database (using NLM MeSH Indexing): Constriction, Pathologic - etiology; Enterocolitis, Pseudomembranous - pathology; Female - pathology; Humans - pathology; Infant - pathology; Infant, Newborn - pathology; Intestine, Large - pathology; Intestine, Small - pathology; Male - pathology; Time Factors - pathology; Treatment Outcome - pathology
Find related publications in this database (Keywords): Late Intestinal Strictures; Necrotizing Enterocolitis