Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krasteva, I; Bratkov, V; Bucar, F; Kunert, O; Kollroser, M; Kondeva-Burdina, M; Ionkova, I.
Flavoalkaloids and Flavonoids from Astragalus monspessulanus.
J Nat Prod. 2015; 78(11):2565-2571
Doi: 10.1021/acs.jnatprod.5b00502
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Kollroser Manfred
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- Abstract:
- A new flavonol tetraglycoside, quercetin-3-O-[α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranosyl]-7-O-β-D-glucopyranoside (1), and two new flavonol alkaloids, N-(8-methylquercetin-3-O-[α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranosyl])-3-hydroxypiperidin-2-one (2) and N-(8-methylkaempferol-3-O-[α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranosyl])-3-hydroxypiperidin-2-one (3), were isolated from the aerial parts of Astragalus monspessulanus ssp. monspessulanus. Two rare flavonoids with an unusual 3-hydroxy-3-methylglutaric acid moiety, quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-[6-O-(3-hydroxy-3-methylglutaryl)-β-D-galactopyranoside (4) and kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-[6-O-(3-hydroxy-3-methylglutaryl)-β-D-galactopyranoside (5), were isolated from the aerial parts of A. monspessulanus ssp. illyricus. In addition, the eight known flavonoids alangiflavoside (6), alcesefoliside (7), mauritianin (8), quercetin-3-β-robinobioside (9), cosmosine (10), apigenin-4'-O-glucoside (11), trifolin (12), and rutin (13) were isolated from aerial parts of A. monspessulanus ssp. monspessulanus. Their structures were elucidated via NMR and HRESIMS data. In a model that tested t-BuOOH-induced oxidative stress on isolated rat hepatocytes, flavonoids 1-13 had statistically significant cytoprotective activity similar to that of silymarin, tested at 60 μg/mL. The most prominent effects were observed for flavonoids 1, 4, 7, and 12.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Astragalus Plant - chemistry
- Astragalus Plant -
- Cytoprotection -
- Flavonoids - chemistry
- Flavonoids - isolation & purification
- Flavonoids - pharmacology
- Flavonols - chemistry
- Glucosides - chemistry
- Glucosides - isolation & purification
- Glucosides - pharmacology
- Male -
- Molecular Structure -
- Nuclear Magnetic Resonance, Biomolecular -
- Plant Components, Aerial - chemistry
- Quercetin - analogs & derivatives
- Quercetin - chemistry
- Rats -
- Rats, Wistar -
- Stereoisomerism -