Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Traylor, M; Zhang, CR; Adib-Samii, P; Devan, WJ; Parsons, OE; Lanfranconi, S; Gregory, S; Cloonan, L; Falcone, GJ; Radmanesh, F; Fitzpatrick, K; Kanakis, A; Barrick, TR; Moynihan, B; Lewis, CM; Boncoraglio, GB; Lemmens, R; Thijs, V; Sudlow, C; Wardlaw, J; Rothwell, PM; Meschia, JF; Worrall, BB; Levi, C; Bevan, S; Furie, KL; Dichgans, M; Rosand, J; Markus, HS; Rost, N; International Stroke Genetics Consortium.
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Neurology. 2016; 86(2):146-153
Doi: 10.1212/WNL.0000000000002263
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Mitglieder der Med Uni Graz:
- Enzinger Christian
- Pichler Alexander
- Schmidt Helena
- Schmidt Reinhold
- Seiler Stephan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations. There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (p < 5 × 10(-6)) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [NBEAL1], p = 2.2 × 10(-8); rs941898 [EVL], p = 4.0 × 10(-8); rs962888 [C1QL1], p = 1.1 × 10(-8); rs9515201 [COL4A2], p = 6.9 × 10(-9)). Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease. © 2015 American Academy of Neurology.
- Find related publications in this database (using NLM MeSH Indexing)
- Cerebral Small Vessel Diseases - genetics
- Genetic Predisposition to Disease - genetics
- Genetic Testing - methods
- Genome-Wide Association Study -
- Humans -
- Polymorphism, Single Nucleotide - genetics
- Risk Factors -
- Stroke - epidemiology
- Stroke - physiopathology
- White Matter - physiopathology