Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Grangl, G; Zöhrer, E; Köstenberger, M; Jud, A; Fauler, G; Scharnagl, H; Stojakovic, T; Marterer, R; Gamillscheg, A; Jahnel, J.
Serum Bile Acids in Repaired Tetralogy of Fallot: A Marker for Liver and Heart?
PLoS One. 2015; 10(12):e0144745-e0144745
Doi: 10.1371/journal.pone.0144745
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- Leading authors Med Uni Graz
- Grangl Gernot
- Jahnel Jörg
- Zöhrer Evelyn
- Co-authors Med Uni Graz
- Fauler Günter
- Gamillscheg Andreas
- Koestenberger Martin
- Marterer Robert
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- Patients with repaired tetralogy of Fallot may develop chronic right ventricular dysfunction and hepatic congestion over time. We hypothesized that bile acid metabolism is altered in repaired tetralogy of Fallot patients and therefore sought to correlate right ventricular indices with serum bile acid levels. Indexed right ventricular end diastolic volume, as assessed by cardiac magnetic-resonance imaging, was classified as <100ml/m2 (Group 1, n = 5), 100-150ml/m2 (Group 2, n = 18), and >150ml/m2 (Group 3, n = 6) in 29 patients with repaired tetralogy of Fallot. Pulmonary regurgitation fraction and right ventricular ejection fraction were calculated. The serum bile acid profile, including 15 species, in these patients was determined by liquid chromatography coupled with mass spectrometry. Serum bile acid levels increased from Group 1 to Group 3 (2.5 ± 0.7; 4.1 ± 2.5; 6.0 ± 2.8 μmol/l, respectively) with significantly increased bile acid values in Group 3 compared to Group 1 (p≤0.05). In Group 3, but not in Group 1 and 2, a significant increase in glycine-conjugated bile acids was observed. Pulmonary regurgitation fraction increased (12 ± 1; 28 ± 16; 43 ± 3%, Groups 1-3, respectively) and right ventricular ejection fraction decreased (48.4 ± 6.4; 48.5 ± 6.5; 42.1 ± 5.3%, Groups 1-3, respectively) with rising indexed right ventricular end diastolic volume. These preliminary results suggest that serum bile acid levels are positively correlated with indexed right ventricular end-diastolic volume in patients with repaired tetralogy of Fallot; however, this needs to be confirmed in a larger patient cohort.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Bile Acids and Salts - blood
- Biomarkers - blood
- Child -
- Chromatography, Liquid -
- Female -
- Humans -
- Liver - metabolism
- Male -
- Mass Spectrometry -
- Myocardium - metabolism
- Postoperative Complications - blood
- Prospective Studies -
- Pulmonary Valve Insufficiency - blood
- Stroke Volume -
- Tetralogy of Fallot - blood
- Ventricular Function, Right -