Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Parzefall, T; Wolf, A; Czeiger, S; Frei, K; Formanek, M; Erovic, BM.
Effect of postoperative use of diclofenac on pharyngocutaneous fistula development after primary total laryngopharyngectomy: Results of a single-center retrospective study.
Head Neck. 2016; 38 Suppl 1(2):E1515-E1520
Doi: 10.1002/hed.24271
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Wolf Axel
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- Abstract:
- Primary total laryngopharyngectomy is the treatment of choice in many cases of locally advanced hypopharyngeal and laryngeal cancer. Development of pharyngocutaneous fistulae is the most common postoperative complication. A recent Danish study showed significantly increased rates of anastomosal leakage after colorectal resection in patients receiving diclofenac treatment. We retrospectively analyzed 67 patients after primary total laryngopharyngectomy to determine whether diclofenac increases the risk for development of pharyngocutaneous fistula analogously to leakage in the colorectal area. The fistula rate in the total study population (n = 67) was 19.4%. In the group receiving diclofenac postoperatively (n = 31), the fistula rate was 25.8%. In the patient group not receiving diclofenac (n = 36), the fistula rate was 13.9% (p = .219). Our results suggest that cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs (NSAIDs) should be administered with caution after laryngopharyngectomy. Additional studies on larger cohorts are required to further evaluate our findings. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1515-E1520, 2016. © 2015 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Cutaneous Fistula - drug therapy
- Cutaneous Fistula - prevention & control
- Diclofenac - therapeutic use
- Female -
- Humans -
- Laryngeal Neoplasms - surgery
- Laryngectomy - adverse effects
- Male -
- Middle Aged -
- Pharyngeal Neoplasms - surgery
- Pharyngectomy - adverse effects
- Postoperative Care -
- Postoperative Complications -
- Retrospective Studies -
- Find related publications in this database (Keywords)
- primary laryngectomy
- laryngopharyngectomy
- pharyngocutaneous fistula
- nonsteroidal anti-inflammatory drug (NSAID)
- diclofenac