Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krones, E; Fickert, P; Zitta, S; Neunherz, S; Artinger, K; Reibnegger, G; Durchschein, F; Wagner, D; Stojakovic, T; Stadlbauer, V; Fauler, G; Stauber, R; Zollner, G; Kniepeiss, D; Rosenkranz, AR.
The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis.
BMC Nephrol. 2015; 16(4):196-196
Doi: 10.1186/s12882-015-0188-0
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- Führende Autor*innen der Med Uni Graz
- Rosenkranz Alexander
- Tatscher Elisabeth
- Co-Autor*innen der Med Uni Graz
- Artinger Katharina
- Baumann-Durchschein Franziska
- Fauler Günter
- Fickert Peter
- Kniepeiss Daniela
- Reibnegger Gilbert
- Stadlbauer-Köllner Vanessa
- Stauber Rudolf
- Stojakovic Tatjana
- Wagner Doris
- Zitta Sabine
- Zollner Gernot
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- Abstract:
- Accurate measurement of renal function in cirrhotic patients is still challenging. To find the best test for the determination of the true glomerular filtration rate (GFR) in cirrhotic patients this study prospectively compared measured (m)GFR, the gold standard, with estimated (e)GFR using equations based on serum levels of creatinine and cystatin C. GFR was measured by sinistrin clearance using the bolus method in 50 patients with cirrhosis (Child Turcotte Pugh score A, B and C) and 24 age-matched healthy subjects as controls. Measured (m)GFR was compared to eGFR using bias, accuracy 10 % and 30 %, as well as correlation coefficients. Creatinine-based equations generally overestimated GFR in patients with cirrhosis and showed a bias (average difference between mGFR and eGFR) of -40 (CG), -12 (MDRD) and -9 (CKD-EPI-Cr) ml/min/1.73 m(2). Cystatin C-based equations underestimated GFR, especially in patients with Child Turcotte Pugh score C (bias 17 ml/min/1.73 m(2)for CKD-EPI-CysC). Of these equations, the CKD-EPI equation that combines creatinine and cystatin C (CKD-EPI-Cr-CysC) showed a bias of 0.12 ml/min/1.73 m(2) as compared to measured GFR. The CKD-EPI equation that combines serum creatinine and cystatin C measurements shows the best performance for accurate estimation of GFR in cirrhosis, especially at advanced stages.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged - epidemiology
- Biomarkers -
- Comorbidity -
- Creatinine - blood
- Cystatin C - blood
- Diagnosis, Computer-Assisted - methods
- Epidemiologic Research Design -
- Female -
- Glomerular Filtration Rate -
- Humans -
- Liver Cirrhosis - blood
- Liver Cirrhosis - diagnosis
- Liver Cirrhosis - epidemiology
- Male -
- Middle Aged -
- Prevalence -
- Renal Insufficiency, Chronic - blood
- Renal Insufficiency, Chronic - diagnosis
- Renal Insufficiency, Chronic - epidemiology
- Reproducibility of Results -
- Risk Assessment - methods
- Risk Factors -
- Sensitivity and Specificity -
- Young Adult -
- Find related publications in this database (Keywords)
- Cirrhosis
- Cystatin C
- Glomerular filtration rate
- Renal function
- Clearance
- Sinistrin