Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Thomas, J; Ohtsuka, M; Pichler, M; Ling, H.
MicroRNAs: Clinical Relevance in Colorectal Cancer.
Int J Mol Sci. 2015; 16(12):28063-28076
Doi: 10.3390/ijms161226080
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Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Pichler Martin
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- Abstract:
- Colorectal cancer is one of the most common cancer diagnoses and causes of mortality worldwide. MicroRNAs are a class of small, non-coding regulatory RNAs that have shown strong associations with colorectal cancer. Through the repression of target messenger RNAs, microRNAs modulate many cellular pathways, such as those involved in cell proliferation, apoptosis, and differentiation. The utilization of microRNAs has shown significant promise in the diagnosis and prognosis of colorectal cancer, owing to their unique expression profile associations with cancer types and malignancies. Moreover, microRNA therapeutics with mimics or antagonists show great promise in preclinical studies, which encourages further development of their clinical use for colorectal cancer patients. The unique ability of microRNAs to affect multiple downstream pathways represents a novel approach for cancer therapy. Although still early in its development, we believe that microRNAs can be used in the near future as biomarkers and therapeutic targets for colorectal cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Transformation, Neoplastic - genetics
- Colorectal Neoplasms - diagnosis
- Colorectal Neoplasms - drug therapy
- Colorectal Neoplasms - genetics
- Colorectal Neoplasms - metabolism
- Colorectal Neoplasms - mortality
- Disease Progression -
- Drug Resistance, Neoplasm - genetics
- Gene Expression Regulation, Neoplastic -
- Genes, Tumor Suppressor -
- Genetic Association Studies -
- Humans -
- MicroRNAs - genetics
- Molecular Targeted Therapy -
- Oncogenes -
- Prognosis -
- Signal Transduction -
- Find related publications in this database (Keywords)
- colorectal cancer
- miRNA
- pathophysiology
- diagnosis
- prognosis
- treatment