Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Roten, L; Derval, N; Maury, P; Mahida, S; Pascale, P; Leenhardt, A; Jesel, L; Deisenhofer, I; Kautzner, J; Probst, V; Rollin, A; Ruidavets, JB; Ferrières, J; Sacher, F; Heg, D; Scherr, D; Komatsu, Y; Daly, M; Denis, A; Shah, A; Hocini, M; Jaïs, P; Haïssaguerre, M.
Benign vs. malignant inferolateral early repolarization: Focus on the T wave.
Heart Rhythm. 2016; 13(4):894-902
Doi: 10.1016/j.hrthm.2015.11.020
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- Co-Autor*innen der Med Uni Graz
- Scherr Daniel
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- Abstract:
- Inferolateral early repolarization (ER) is highly prevalent and is associated with idiopathic ventricular fibrillation (VF). The purpose of this study was to evaluate the potential role of T-wave parameters to differentiate between malignant and benign ER. We compared the ECGs of patients with ER and VF (n = 92) with control subjects with asymptomatic ER (n = 247). We assessed J-wave amplitude, QTc interval, T-wave/R-wave (T/R) ratio in leads II and V5, and presence of low-amplitude T waves (T-wave amplitude <0.1 mV and <10% of R-wave amplitude in lead I, II, or V4-V6). Compared to controls, the VF group had longer QTc intervals (388 ms vs. 377 ms, P = .001), higher J-wave amplitudes (0.23 mV vs. 0.17 mV, P <.001), higher prevalence of low-amplitude T waves (29% vs. 3%, P <.001), and lower T/R ratio (0.18 vs. 0.30, P <.001). Logistic regression analysis demonstrated that QTc interval (odds ratio [OR] per 10 ms: 1.15, 95% confidence interval [CI} 1.02-1.30), maximal J-wave amplitude (OR per 0.1 mV: 1.68, 95% CI 1.23-2.31), lower T/R ratio (OR per 0.1 unit: 0.62, 95% CI 0.47-0.81), presence of low-amplitude T waves (OR 3.53, 95% CI 1.26-9.88). and presence of J waves in the inferior leads (OR 2.58, 95% CI 1.18-5.65) were associated with malignant ER. Patients with malignant ER have a higher prevalence of low-amplitude T waves, lower T/R ratio (lead II or V5), and longer QTc interval. The combination of these parameters with J-wave amplitude and distribution of J waves may allow for improved identification of malignant ER. Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Europe - epidemiology
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- Middle Aged -
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- Survival Rate - trends
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- Find related publications in this database (Keywords)
- J wave
- Early repolarization
- Ventricular fibrillation
- Electrocardiogram
- QT interval