Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brcic, I; Cathomas, G; Vanoli, A; Jilek, K; Giuffrida, P; Langner, C.
Medullary carcinoma of the small bowel.
Histopathology. 2016; 69(1): 136-140.
Doi: 10.1111/his.12908
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Brcic Iva
- Co-Autor*innen der Med Uni Graz
- Langner Cord
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- Abstract:
- Medullary carcinoma of the large bowel occurs mainly right-sided in elderly females. The tumour is almost invariably microsatellite instable and has been associated with favourable outcome. Our study aimed to present three cases of medullary carcinoma originating from the small bowel. We describe three cases of small bowel medullary carcinoma. Two patients had coeliac disease, diagnosed at the ages of 79 and 71 years, respectively. The tumours showed the characteristic syncytial growth pattern with marked intratumoral lymphocytic inflammation. Loss of MutL homologue 1 (MLH1) [and postmeiotic segregation increased 2 (S. cerevisiae) PMS2] expression was observed in all cases, consistent with high-level microsatellite instability. All tumours were negative for Epstein-Barr virus. Follow-up information was available for one patient, who is recurrence-free 6 years after resection. Medullary carcinoma of the small bowel is exceedingly rare. Our data and a review of the literature suggest that this tumour type is characteristic for coeliac disease and may be the histological type underlying small bowel cancers with high-level microsatellite instability in patients with coeliac disease. © 2015 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Carcinoma, Medullary - diagnosis
- Carcinoma, Medullary - genetics
- Carcinoma, Medullary - metabolism
- Celiac Disease - diagnosis
- Celiac Disease - genetics
- Celiac Disease - metabolism
- Female -
- Humans -
- Intestinal Neoplasms - diagnosis
- Intestinal Neoplasms - genetics
- Intestinal Neoplasms - metabolism
- Intestine, Small - metabolism
- Intestine, Small - pathology
- Male -
- Microsatellite Instability -
- Middle Aged -
- Find related publications in this database (Keywords)
- coeliac disease
- ileum
- jejunum
- medullary carcinoma
- microsatellite instability