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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ebner, T; Tritscher, K; Mayer, RB; Oppelt, P; Duba, HC; Maurer, M; Schappacher-Tilp, G; Petek, E; Shebl, O.
Quantitative and qualitative trophectoderm grading allows for prediction of live birth and gender.
J Assist Reprod Genet. 2016; 33(1):49-57
Doi: 10.1007/s10815-015-0609-9
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- Leading authors Med Uni Graz
- Ebner Thomas
- Co-authors Med Uni Graz
- Petek Erwin
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- Abstract:
- Prolonged in vitro culture is thought to affect pre- and postnatal development of the embryo. This prospective study was set up to determine whether quality/size of inner cell mass (ICM) (from which the fetus ultimately develops) and trophectoderm (TE) (from which the placenta ultimately develops) is reflected in birth and placental weight, healthy live-birth rate, and gender after fresh and frozen single blastocyst transfer. In 225 patients, qualitative scoring of blastocysts was done according to the criteria expansion, ICM, and TE appearance. In parallel, all three parameters were quantified semi-automatically. TE quality and cell number were the only parameters that predicted treatment outcome. In detail, pregnancies that continued on to a live birth could be distinguished from those pregnancies that aborted on the basis of TE grade and cell number. Male blastocysts had a 2.53 higher chance of showing TE of quality A compared to female ones. There was no correlation between the appearance of both cell lineages and birth or placental weight, respectively. The presented correlation of TE with outcome indicates that TE scoring could replace ICM scoring in terms of priority. This would automatically require a rethinking process in terms of blastocyst selection and cryopreservation strategy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blastocyst Inner Cell Mass - cytology
- Blastocyst Inner Cell Mass - metabolism
- Cryopreservation -
- Ectoderm - cytology
- Ectoderm - metabolism
- Embryo Implantation - physiology
- Embryo Transfer - methods
- Female -
- Fertilization in Vitro - methods
- Humans -
- Live Birth - epidemiology
- Male -
- Middle Aged -
- Pregnancy -
- Pregnancy Rate -
- Sex Determination Processes -
- Find related publications in this database (Keywords)
- Blastocyst
- Inner cell mass
- Live-birth
- Neonatal outcome
- Trophectoderm