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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Catena, C; Colussi, G; Url-Michitsch, M; Nait, F; Sechi, LA.
Subclinical carotid artery disease and plasma homocysteine levels in patients with hypertension.
J Am Soc Hypertens. 2015; 9(3):167-175
Doi: 10.1016/j.jash.2014.12.020
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Url-Michitsch Marion
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- Abstract:
- Information on the association between homocysteine (Hcy) levels and subclinical carotid artery disease is limited. We investigated the relationship of plasma Hcy concentration with carotid artery plaques and intima-media thickness (IMT) in patients with hypertension. In 486 essential hypertensive patients who underwent ultrasound examination of the carotid arteries, we measured plasma levels of Hcy, vitamin B12, folate, and C-reactive protein. Plaques were detected in 34% of the study patients. Plasma Hcy levels were significantly greater in hypertensive patients with evidence of carotid plaques than patients without carotid plaques. Carotid IMT progressively increased across quartiles of plasma Hcy levels. Multivariate regression showed that carotid IMT was independently related with age, blood pressure, C-reactive protein, and Hcy levels. In a logistic regression, age, blood pressure, triglyceride, and Hcy independently predicted the presence of carotid plaques. Thus, elevated plasma Hcy levels are associated with asymptomatic carotid disease in hypertensive patients suggesting a role of Hcy in the development and progression of carotid atherosclerosis in these patients. Copyright © 2015 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Asymptomatic Diseases -
- Austria -
- C-Reactive Protein - metabolism
- Carotid Arteries - diagnostic imaging
- Carotid Arteries - pathology
- Carotid Intima-Media Thickness -
- Carotid Stenosis - blood
- Carotid Stenosis - diagnosis
- Carotid Stenosis - etiology
- Carotid Stenosis - physiopathology
- Cross-Sectional Studies -
- Disease Progression -
- Female -
- Homocysteine - blood
- Humans -
- Hypertension - complications
- Hypertension - metabolism
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Risk Factors -
- Statistics as Topic -
- Find related publications in this database (Keywords)
- Atherosclerosis
- carotid plaques
- cerebrovascular disease
- intima-media thickness