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Simmons, D; Jelsma, JG; Galjaard, S; Devlieger, R; van Assche, A; Jans, G; Corcoy, R; Adelantado, JM; Dunne, F; Desoye, G; Harreiter, J; Kautzky-Willer, A; Damm, P; Mathiesen, ER; Jensen, DM; Andersen, LL; Lapolla, A; Dalfra, M; Bertolotto, A; Wender-Ozegowska, E; Zawiejska, A; Hill, D; Rebollo, P; Snoek, FJ; van Poppel, MN.
Results From a European Multicenter Randomized Trial of Physical Activity and/or Healthy Eating to Reduce the Risk of Gestational Diabetes Mellitus: The DALI Lifestyle Pilot.
Diabetes Care. 2015; 38(9):1650-1656 Doi: 10.2337/dc15-0360 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Desoye Gernot
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Abstract:: Ways to prevent gestational diabetes mellitus (GDM) remain unproven. We compared the impact of three lifestyle interventions (healthy eating [HE], physical activity [PA], and both HE and PA [HE+PA]) on GDM risk in a pilot multicenter randomized trial. Pregnant women at risk for GDM (BMI ≥29 kg/m2) from nine European countries were invited to undertake a 75-g oral glucose tolerance test before 20 weeks' gestation. Those without GDM were randomized to HE, PA, or HE+PA. Women received five face-to-face and four optional telephone coaching sessions, based on the principles of motivational interviewing. A gestational weight gain (GWG) <5 kg was targeted. Coaches received standardized training and an intervention toolkit. Primary outcome measures were GWG, fasting glucose, and insulin sensitivity (HOMA) at 35-37 weeks. Among the 150 trial participants, 32% developed GDM by 35-37 weeks and 20% achieved GWG <5 kg. HE women had less GWG (-2.6 kg [95% CI -4.9, -0.2]; P = 0.03) and lower fasting glucose (-0.3 mmol/L [-0.4, -0.1]; P = 0.01) than those in the PA group at 24-28 weeks. HOMA was comparable. No significant differences between HE+PA and the other groups were observed. An antenatal HE intervention is associated with less GWG and lower fasting glucose compared with PA alone. These findings require a larger trial for confirmation but support the use of early HE interventions in obese pregnant women. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Diabetes, Gestational - epidemiology; Diabetes, Gestational - prevention & control; Europe -; Feeding Behavior - physiology; Female -; Glucose Tolerance Test -; Humans -; Insulin Resistance -; Life Style -; Motivational Interviewing -; Motor Activity -; Obesity - complications; Obesity - prevention & control; Pilot Projects -; Pregnancy -; Risk Reduction Behavior -; Weight Gain -