Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hadji, P; Papaioannou, N; Gielen, E; Feudjo Tepie, M; Zhang, E; Frieling, I; Geusens, P; Makras, P; Resch, H; Möller, G; Kalouche-Khalil, L; Fahrleitner-Pammer, A.
Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study.
Osteoporos Int. 2015; 26(10):2479-2489
Doi: 10.1007/s00198-015-3164-4
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fahrleitner-Pammer Astrid
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Persistence with and adherence to osteoporosis therapy are critical for fracture reduction. This non-interventional study is evaluating medication-taking behavior of women with postmenopausal osteoporosis (PMO) receiving denosumab in Germany, Austria, Greece, and Belgium. Patients were representative of the PMO population and highly persistent with and adherent to denosumab at 12 months. Persistence with and adherence to osteoporosis therapy are important for optimal treatment efficacy, namely fracture reduction. This ongoing, non-interventional study will evaluate medication-taking behavior of women with postmenopausal osteoporosis (PMO) receiving denosumab in routine practice in four European countries. The study enrolled women who had been prescribed subcutaneous denosumab (60 mg every 6 months) in accordance with prescribing information and local guidelines. Persistence was defined as receiving the subsequent injection within 6 months + 8 weeks of the previous injection. Adherence was defined as receiving two consecutive injections within 6 months ± 4 weeks of each other. Medication coverage ratio (MCR) was calculated using the time a patient was covered with denosumab, as assessed from prescription records. Treatment was assigned prior to and independently of enrollment; outcomes are recorded during routine practice. These planned 12-month interim analyses included data from 1500 patients from 141 sites. Mean age was 66.4-72.4 years, mean baseline total hip T-scores ranged from -2.0 to -2.1 and femoral neck T-scores from -2.2 to -2.6, and 30.7-62.1% of patients had prior osteoporotic fracture. Persistence was 87.0-95.3%, adherence 82.7-89.3%, and MCR 91.3-95.4%. In a univariate analysis, increased age, decreased mobility, and increased distance to the clinic were associated with significantly decreased persistence; parental history of hip fracture was associated with significantly increased persistence. These data extend the real-world evidence regarding persistence with and adherence to denosumab, both of which are critical for favorable clinical outcomes, including fracture risk reduction.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Bone Density Conservation Agents - administration & dosage
- Bone Density Conservation Agents - adverse effects
- Bone Density Conservation Agents - therapeutic use
- Comorbidity -
- Denosumab - administration & dosage
- Denosumab - adverse effects
- Denosumab - therapeutic use
- Drug Administration Schedule -
- Drug Administration Schedule - epidemiology
- Female -
- Humans -
- Injections, Subcutaneous -
- Medication Adherence - statistics & numerical data
- Medicine - statistics & numerical data
- Middle Aged -
- Osteoporosis, Postmenopausal - drug therapy
- Osteoporosis, Postmenopausal - epidemiology
- Osteoporosis, Postmenopausal - psychology
- Osteoporotic Fractures - epidemiology
- Osteoporotic Fractures - prevention & control
- Prospective Studies -
- Find related publications in this database (Keywords)
- Adherence
- Compliance
- Denosumab
- Non-interventional study
- Osteoporosis
- Persistence