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SHR Neuro Cancer Cardio Lipid Metab Microb
Resch, B; Gutmann, C; Reiterer, F; Luxner, J; Urlesberger, B.
Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics.
Infection. 2016; 44(3):323-327
Doi: 10.1007/s15010-015-0858-7
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- Leading authors Med Uni Graz
- Resch Bernhard
- Co-authors Med Uni Graz
- Luxner Josefa
- Reiterer Friedrich
- Urlesberger Berndt
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- Abstract:
- To evaluate the influence of Ureaplasma urealyticum (UU) colonization on neonatal pulmonary and cerebral morbidity. Single-center case-control study including all preterm infants with positive UU tracheal colonization between 1990 and 2012. Cases were matched with controls by birth year, gestational age, birth weight, and sex. All cases had received macrolide antibiotics for UU infection starting at the time of first positive culture results from tracheal aspirates. Main outcome parameters included presence and severity of hyaline membrane disease (IRDS), duration of ventilation, bronchopulmonary dysplasia at 36 postmenstrual age and neurological morbidities (seizures, intra-/periventricular hemorrhages-I/PVH, periventricular leukomalacia-PVL). Of 74 cases identified 8 died and 4 had to be excluded; thus, 62 preterm infants were compared to 62 matched controls. UU was significantly associated with IRDS (79 vs. 61 %, p = 0.015), BPD (24 vs. 6 %, p = 0.003), seizures (23 vs. 5 %, p = 0.002) and I/PVH (45 vs. 24 %, p = 0.028). Cases had longer duration of mechanical ventilation and total duration of invasive and non-invasive ventilation (median 11 vs. 6 days p = 0.006 and 25 vs. 16.5 days p = 0.019, respectively). UU was found to be significantly associated with pulmonary short- and long-term morbidity and mild cerebral impairment despite treatment with macrolide antibiotics.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - therapeutic use
- Bronchopulmonary Dysplasia - complications
- Bronchopulmonary Dysplasia - epidemiology
- Case-Control Studies -
- Female -
- Humans -
- Infant, Newborn -
- Infant, Newborn, Diseases - drug therapy
- Infant, Newborn, Diseases - epidemiology
- Infant, Newborn, Diseases - microbiology
- Macrolides - therapeutic use
- Male -
- Respiratory Distress Syndrome, Newborn - complications
- Respiratory Distress Syndrome, Newborn - epidemiology
- Retrospective Studies -
- Treatment Outcome -
- Ureaplasma Infections - complications
- Ureaplasma Infections - drug therapy
- Ureaplasma Infections - epidemiology
- Ureaplasma Infections - microbiology
- Ureaplasma urealyticum -
- Find related publications in this database (Keywords)
- Ureaplasma urealyticum
- Erythromycin
- Respiratory distress syndrome
- Bronchopulmonary dysplasia
- Intraventricular hemorrhage