Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Hoenigl, M; Chaillon, A; Moore, DJ; Morris, SR; Smith, DM; Little, SJ.
Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men.
J Acquir Immune Defic Syndr. 2016; 71(5):551-557
Doi: 10.1097/QAI.0000000000000888
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- It remains unclear if methamphetamine is merely associated with high-risk behavior or if methamphetamine use causes high-risk behavior. Determining this would require a randomized controlled trial, which is clearly not ethical. A possible surrogate would be to investigate individuals before and after starting the use of methamphetamine. We performed a cohort study to analyze recent self-reported methamphetamine use and sexual risk behavior among 8905 men who have sex with men (MSM) receiving the "Early Test," a community-based HIV screening program in San Diego, CA, between April 2008 and July 2014 (total 17,272 testing encounters). Sexual risk behavior was evaluated using a previously published risk behavior score [San Diego Early Test (SDET) score] that predicts risk of HIV acquisition. Methamphetamine use during the last 12 months (hereafter, recent-meth) was reported by 754/8905 unique MSM (8.5%). SDET scores were significantly higher in the 754 MSM with recent-meth use compared with the 5922 MSM who reported that they have never used methamphetamine (P < 0.001). Eighty-two repeat testers initiated methamphetamine between testing encounter, with significantly higher SDET scores after starting methamphetamine [median 5 (interquartile range, 2-7) at recent-meth versus median 3 (interquartile range, 0-5) at never-meth; P < 0.001, respectively]. Given the ethical impossibility of conducting a randomized controlled trial, the results presented here provide the strongest evidence yet that initiation of methamphetamine use increases sexual risk behavior among HIV-uninfected MSM. Until more effective prevention or treatment interventions are available for methamphetamine users, HIV-uninfected MSM who use methamphetamine may represent ideal candidates for alternative effective prevention interventions (ie, preexposure prophylaxis).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amphetamine-Related Disorders - complications
- Cohort Studies -
- HIV Infections - prevention & control
- Homosexuality, Male - statistics & numerical data
- Humans -
- Male -
- Methamphetamine - adverse effects
- Middle Aged -
- ROC Curve -
- Retrospective Studies -
- Risk-Taking -
- Unsafe Sex - statistics & numerical data
- Find related publications in this database (Keywords)
- risk behavior
- methamphetamine
- MSM
- recreational drugs
- stimulants
- SDET score