Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wenzl, K; Hofer, S; Troppan, K; Lassnig, M; Steinbauer, E; Wiltgen, M; Zulus, B; Renner, W; Beham-Schmid, C; Neumeister, P; Deutsch, A.
Higher incidence of the SNP Met 788 Ile in the coding region of A20 in diffuse large B cell lymphomas.
Tumour Biol. 2016; 37(4):4785-4789
Doi: 10.1007/s13277-015-4322-1
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- Führende Autor*innen der Med Uni Graz
- Deutsch Alexander
- Wenzl Kerstin
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Hofer Sybille
- Neumeister Peter
- Prochazka Katharina
- Renner Wilfried
- Steinbauer Elisabeth
- Wiltgen Marco
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- Abstract:
- Genetic alterations causing constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway has been associated with the development of lymphomas. A20 (TNFAIP3) is a key regulator of NF-κB signaling. Its suppressor functions are often inactivated by deletions and/or mutations in various hematologic malignancies. Since we recently found the rs143002189 polymorphism in the A20 loci in our multiple myeloma samples, we further investigated this polymorphism in different lymphoid neoplasias. For this purpose, we tested 479 cases of the most common B cell malignancies for the presence of the rs143002189 polymorphism. We found a significant higher occurrence of the rs143002189 polymorphism in diffuse large B cell lymphoma (DLBCL) compared to non-neoplastic controls and other types of B cell malignancies. Furthermore, structure analyses of the mutated A20 protein led to the assumption that the new steric interaction within the protein is responsible for a reduced or inactivated A20 protein. Our data indicates that in a significant fraction of patients, rs143002189 might contribute to the development of DLBCL.
- Find related publications in this database (using NLM MeSH Indexing)
- Case-Control Studies -
- Genetic Association Studies -
- Genetic Predisposition to Disease -
- Humans -
- Incidence -
- Lymphoma, Large B-Cell, Diffuse - epidemiology
- Lymphoma, Large B-Cell, Diffuse - genetics
- Models, Molecular -
- Open Reading Frames -
- Polymorphism, Single Nucleotide -
- Tumor Necrosis Factor alpha-Induced Protein 3 - genetics
- Find related publications in this database (Keywords)
- A20
- Polymorphism
- Lymphoma
- DLBCL