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Lang, PF; Mäkinen, JI; Irjala, KM; Rantala, M; Hönigl, W; Tamussino, K; Haas, J.
Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG < or = 2500 mIU/mL.
Acta Obstet Gynecol Scand. 1997; 76(8):797-800 Doi: 10.3109/00016349709024350
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Co-authors Med Uni Graz: Haas Josef; Hoenigl Werner; Tamussino Karl
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Abstract:: OBJECTIVE: To compare expectant management with local instillation of 50% glucose solution for tubal pregnancies with a serum hCG level < or = 2500 mIU/mL. DESIGN: Prospective, non-randomized, comparative clinical study. SETTING: Two university departments. PATIENTS: One hundred and twenty-eight patients with laparoscopically-confirmed tubal pregnancy and serum hCG < or = 2500 mIU/mL. INTERVENTIONS: Eighty patients in Graz were treated with laparoscopic instillation of 50% glucose solution and 48 patients in Turku were followed expectantly. MAIN OUTCOME MEASURES: Resolution of hCG excretion, need for further interventions. RESULTS: Seventy-four of the 80 patients (92%) in the glucose group (32 of 33 with an initial hCG < or = 250 mIU/mL and 42 of 47 with hCG 251-2500 mIU/mL) and 36 of 48 (75%) patients in the expectant group (19 of 23 with an initial hCG < or = 250 mIU/mL and 17 of 25 with hCG 251-2500 mIU/mL) had resolution of the pregnancy with no further intervention (p=0.008, chi-square test, odds ratio 0.24). CONCLUSIONS: Glucose instillation is superior to expectant management for patients with early tubal pregnancy.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Austria -; Chorionic Gonadotropin - blood; Dose-Response Relationship, Drug - blood; Female - blood; Finland - blood; Glucose - administration and dosage; Humans - administration and dosage; Middle Aged - administration and dosage; Osmolar Concentration - administration and dosage; Pregnancy - administration and dosage; Pregnancy, Tubal - drug therapy; Prospective Studies - drug therapy; Ultrasonography, Prenatal - drug therapy
Find related publications in this database (Keywords): Ectopic Pregnancy; Expectant Management; Glucose Installation; HCG Levels; Spontaneous Reaction; Tubal Pregnancy