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SHR Neuro Cancer Cardio Lipid Metab Microb

Kotowski, U; Heiduschka, G; Seemann, R; Eckl-Dorna, J; Schmid, R; Kranebitter, V; Stanisz, I; Brunner, M; Lill, C; Thurnher, D.
Effect of the coffee ingredient cafestol on head and neck squamous cell carcinoma cell lines.
Strahlenther Onkol. 2015; 191(6):511-517 Doi: 10.1007/s00066-014-0807-x
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Thurnher Dietmar
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Abstract:: Cafestol is a diterpene molecule found in coffee beans and has anticarcinogenic properties. The aim of the study was to examine the effects of cafestol in head and neck squamous cell carcinoma (HNSCC) cells. Three HNSCC cell lines (SCC25, CAL27 and FaDu) were treated with increasing doses of cafestol. Then combination experiments with cisplatin and irradiation were carried out. Drug interactions and possible synergy were calculated using the combination index analysis. Clonogenic assays were performed after irradiation with 2, 4, 6 and 8 Gy, respectively, and the rate of apoptosis was measured with flow cytometry. Treatment of HNSCC cells with cafestol leads to a dose-dependent reduction of cell viability and to induction of apoptosis. Combination with irradiation shows a reduction of clonogenic survival compared to each treatment method alone. In two of the cell lines a significant additive effect was observed. Cafestol is a naturally occurring effective compound with growth-inhibiting properties in head and neck cancer cells. Moreover, it leads to a significant inhibition of colony formation.
Find related publications in this database (using NLM MeSH Indexing): Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - physiopathology; Cell Line, Tumor -; Cell Proliferation - drug effects; Cell Proliferation - radiation effects; Chemoradiotherapy - methods; Coffee - chemistry; Diterpenes - administration & dosage; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - physiopathology; Humans -; Treatment Outcome -
Find related publications in this database (Keywords): Phytochemicals; Irradiation; Head and neck cancer; Cytotoxins; Cisplatin