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SHR Neuro Cancer Cardio Lipid Metab Microb
Schneider, S; Thurnher, D; Seemann, R; Brunner, M; Kadletz, L; Ghanim, B; Aumayr, K; Heiduschka, G; Lill, C.
The prognostic significance of β-catenin, cyclin D1 and PIN1 in minor salivary gland carcinoma: β-catenin predicts overall survival.
Eur Arch Otorhinolaryngol. 2016; 273(5):1283-1292
Doi: 10.1007/s00405-015-3609-6
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- Co-authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Minor salivary gland carcinoma is a rare and heterogeneous type of cancer. Molecular prognostic and predictive markers are sparse. The aim of this study was to identify new prognostic and predictive markers in minor salivary gland carcinoma. 50 tissue samples of carcinomas of the minor salivary glands (adenoid cystic carcinoma n = 23, mucoepidermoid carcinoma n = 12, adenocarcinoma n = 10, carcinoma ex pleomorphic adenoma n = 2, salivary duct carcinoma n = 1, clear cell carcinoma n = 1, basal cell carcinoma n = 1) were immunohistochemically stained for β-catenin, cyclin D1 and PIN1. Expression patterns were analyzed and correlated to clinical outcome of 37 patients with complete clinical data. High expression of membranous β-catenin was linked to significantly better overall survival in patients with adenoid cystic carcinoma (log rank test, χ (2) = 13.3, p = .00397, Bonferroni corrected p = .024). PIN1 and cyclin D1 did not show any significant correlation to patients' clinical outcome. Expression of β-catenin in adenoid cystic carcinoma of the minor salivary glands significantly correlates with better overall survival. Hence, evaluation of β-catenin might serve as a clinical prognostic marker.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria -
- Biomarkers, Tumor - metabolism
- Carcinoma, Adenoid Cystic - metabolism
- Carcinoma, Adenoid Cystic - pathology
- Cyclin D1 - metabolism
- Female -
- Humans -
- Male -
- Middle Aged -
- NIMA-Interacting Peptidylprolyl Isomerase - metabolism
- Outcome Assessment (Health Care) -
- Predictive Value of Tests -
- Prognosis -
- Retrospective Studies -
- Salivary Gland Neoplasms - metabolism
- Salivary Gland Neoplasms - pathology
- Salivary Glands, Minor - pathology
- Statistics as Topic -
- Survival Analysis -
- beta Catenin - metabolism
- Find related publications in this database (Keywords)
- beta-Catenin
- Cyclin D1
- PIN1
- Minor salivary gland cancer
- Molecular prognostic markers