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SHR Neuro Cancer Cardio Lipid Metab Microb

Lill, C; Schneider, S; Seemann, R; Kadletz, L; Aumayr, K; Ghanim, B; Thurnher, D.
Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland.
Head Neck. 2015; 37(1):30-36 Doi: 10.1002/hed.23546
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Co-authors Med Uni Graz: Thurnher Dietmar
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Abstract:: Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and/or prognostic markers for parotid cancer. A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for ß-catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease-free and overall survival. An overexpression of the cytoplasmatic ß-catenin was linked to a statistically significant worse outcome regarding disease-free (p = .0296) and overall survival (p = .0416). The 5-year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic ß-catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (p = .0306) and disease-free survival (DFS; p = .0473). Multivariate analysis showed that overexpression of cytoplasmatic ß-catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer. © 2014 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Aged, 80 and over -; Carcinoma - metabolism; Carcinoma - mortality; Carcinoma - pathology; Cyclin D1 - metabolism; Disease-Free Survival -; Female -; Humans -; Male -; Middle Aged -; NIMA-Interacting Peptidylprolyl Isomerase -; Parotid Neoplasms - metabolism; Parotid Neoplasms - mortality; Parotid Neoplasms - pathology; Peptidylprolyl Isomerase - metabolism; Retrospective Studies -; Survival Rate -; Young Adult -; beta Catenin - metabolism
Find related publications in this database (Keywords): ss-catenin; Cyclin D1; PIN1; parotid cancer; salivary gland cancer