Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Popper, HH.
[Pulmonary Langerhans cell histiocytosis].
Pathologe. 2015; 36(5):451-457
Doi: 10.1007/s00292-015-0052-9
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- Pulmonary Langerhans cell histiocytosis is regarded as a reactive proliferation of the dendritic Langerhans cell population stimulated by chronic tobacco-derived plant proteins due to incomplete combustion but can also occur in childhood as a tumor-like systemic disease. Currently, both these forms cannot be morphologically distinguished. In the lungs a nodular proliferation of Langerhans cells occurs in the bronchial mucosa and also peripherally in the alveolar septa with an accompanying infiltration by eosinophilic granulocytes and destruction of the bronchial wall. Langerhans cells can be selectively detected with antibodies against CD1a and langerin. In the reactive isolated pulmonary form, abstinence from tobacco smoking in most patients leads to regression of infiltration and improvement of symptoms. In high-resolution computed tomography (HRCT) the small star-like scars can still be detected even after complete cessation of tobacco smoking.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, CD - analysis
- Antigens, CD1 - analysis
- Cell Proliferation - physiology
- Child -
- Dendritic Cells - pathology
- Histiocytosis, Langerhans-Cell - pathology
- Histiocytosis, Langerhans-Cell - therapy
- Humans -
- Langerhans Cells - pathology
- Lectins, C-Type - analysis
- Lung - pathology
- Lung Diseases, Interstitial - pathology
- Lung Diseases, Interstitial - therapy
- Mannose-Binding Lectins - analysis
- Microscopy, Electron -
- Smoking - adverse effects
- Smoking Cessation -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Langerhans cells
- Nodular proliferation
- Tobacco smoking
- CD1a
- Langerin