Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ramlau, R; Cufer, T; Berzinec, P; Dziadziuszko, R; Olszewski, W; Popper, H; Bajcic, P; Dusšk, L; Zbozinkova, Z; Pirker, R; INSIGHT study team.
Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer in the Real-World Setting in Central Europe: The INSIGHT Study.
J Thorac Oncol. 2015; 10(9):1370-1374
Doi: 10.1097/JTO.0000000000000621
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- Co-Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- The ImplementatioN of perSonalized medicine In NSCLC in Central Europe: EGFR testing, Histopathology, and clinical feaTures (INSIGHT) observational study assessed both implementation of epidermal growth factor receptor (EGFR) mutation testing and treatment of patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC) in a real-world setting in Central Europe. A total of 1785 patients from 14 cancer centers of six Central European countries were enrolled. EGFR mutations were detected in tumors of 13.8% of the patients. More than 70% of patients with advanced EGFR mutation-positive NSCLC received EGFR tyrosine kinase inhibitors as first-line therapy. The INSIGHT study demonstrated the establishment of EGFR mutation testing, a mutation rate consistent with other Caucasian patients populations, and adherence to current guidelines regarding treatment of patients with EGFR mutation-positive tumors in Central Europe.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Non-Small-Cell Lung - genetics
- Carcinoma, Non-Small-Cell Lung - pathology
- ErbB Receptors - genetics
- ErbB Receptors - metabolism
- Europe -
- Humans -
- Lung Neoplasms - genetics
- Lung Neoplasms - pathology
- Middle Aged -
- Mutation -
- Young Adult -
- Find related publications in this database (Keywords)
- Targeted therapy
- INSIGHT
- EGFR mutations
- Molecular analysis