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SHR Neuro Cancer Cardio Lipid Metab Microb

Wimmer, T; Srimathveeravalli, G; Silk, M; Monette, S; Gutta, N; Maybody, M; Erinjery, JP; Coleman, JA; Solomon, SB; Sofocleous, CT.
Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.
Technol Cancer Res Treat. 2016; 15(6):749-758 Doi: 10.1177/1533034615608739 [OPEN ACCESS]
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Leading authors Med Uni Graz: Wimmer Thomas
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Abstract:: To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy. Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared. Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm²), although both exhibited similar shape. Computed tomography (standard: 556 ± 61 mm², experimental: 515 ± 67 mm²; P = .25) and histology (standard: 313 ± 77 mm², experimental: 275 ± 75 mm²; P = .29) indicated ablations with experimental probes were not significantly different from the standard. Histopathology indicated similar morphological changes in both groups. Biopsies from the ablation zone yielded at least 1 core with sufficient tissue for analysis (11 of the 20). A combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes. © The Author(s) 2015.
Find related publications in this database (using NLM MeSH Indexing): Ablation Techniques - instrumentation; Ablation Techniques - methods; Animals -; Biopsy, Needle - instrumentation; Biopsy, Needle - methods; Electroporation - instrumentation; Electroporation - methods; Female -; Kidney - surgery; Needles -; Swine -; Tomography, X-Ray Computed - instrumentation; Tomography, X-Ray Computed - methods
Find related publications in this database (Keywords): ablation technique; irreversible electroporation; core needle biopsy; computed tomography; kidney