Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Blaschitz, A; Siwetz, M; Schlenke, P; Gauster, M.
Adhering maternal platelets can contribute to the cytokine and chemokine cocktail released by human first trimester villous placenta.
Placenta. 2015; 36(11):1333-1336
Doi: 10.1016/j.placenta.2015.09.002
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- Führende Autor*innen der Med Uni Graz
- Blaschitz Astrid
- Gauster Martin
- Co-Autor*innen der Med Uni Graz
- Schlenke Peter
- Siwetz Monika
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- Abstract:
- Placental villous explant culture has been increasingly recognized as suitable model to study secretion of inflammatory and immune modulating factors by human placenta. Most of these factors likely derive from the syncytiotrophoblast, whereas extraplacental sources such as maternal peripheral blood cells are rarely considered. Due to their small size and absence of a nucleus, platelets adhering to perivillous fibrinoid of normal placenta are frequently ignored in routine immunohistochemistry. Here we demonstrate adhering maternal platelets on first trimester placental villi after explant culture and point out that platelet-derived factors must be considered when analyzing the inflammatory secretion profile of human placenta. Copyright © 2015 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Platelets - chemistry
- Female -
- Humans -
- Placenta - cytology
- Pregnancy -
- Tissue Culture Techniques -
- Find related publications in this database (Keywords)
- Placental explant culture
- Platelets
- Cytokines
- Chemokines