Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pardeike, J; Strohmeier, DM; Schrödl, N; Voura, C; Gruber, M; Khinast, JG; Zimmer, A.
Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines.
Int J Pharm. 2011; 420(1):93-100
Doi: 10.1016/j.ijpharm.2011.08.033
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Gruber Michael
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- Abstract:
- Folic acid was used as a model drug to demonstrate the advantages of formulating poorly soluble drugs as nanosuspensions and their use in an inkjet-type printing technique to produce personalized medicines. 10% folic acid nanosuspensions stabilized with Tween 20, a stabilizer showing the best wetting potential for folic acid, were prepared via high pressure homogenization. The particle size of the folic acid nanosuspension was well below 5 μm being a prerequisite for inkjet type printing technique. A good reproducibility of the particle size of folic acid nanosuspension prepared via high pressure homogenization was found. As indicated by the zeta potential the formulation showed a good storage stability. High pressure homogenization had no influence on the crystalline state of folic acid. An increase in the saturation solubility by 53.7% was found reducing the particle size from the micrometer range to the nanometer range. The dissolution velocity of the folic acid nanosuspension was significantly enhanced compared to a folic acid suspension, i.e. after 5 min 78.6% of the folic acid was dissolved from the nanosuspension and only 6.2% from the suspension. Moreover, the printing of 10% folic acid nanosuspension could be successfully demonstrated. Copyright © 2011 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Chemistry, Pharmaceutical -
- Crystallization -
- Dosage Forms -
- Drug Compounding -
- Drug Dosage Calculations -
- Drug Stability -
- Excipients - chemistry
- Folic Acid - administration & dosage Folic Acid - chemistry
- Humans -
- Individualized Medicine - methods
- Kinetics -
- Nanoparticles -
- Nanotechnology -
- Polysorbates - chemistry
- Pressure -
- Solubility -
- Technology, Pharmaceutical - methods
- Wetting Agents - chemistry
- Find related publications in this database (Keywords)
- Nanosuspension
- Personalized medicine
- Folic acid
- Dissolution velocity
- Saturation solubility
- Inkjet type printing technique