Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schwameis, R; Grimm, C; Petru, E; Natter, C; Staudigl, C; Lamm, W; Koelbl, H; Krainer, M; Brodowicz, T; Reinthaller, A; Polterauer, S.
The Prognostic Value of C-Reactive Protein Serum Levels in Patients with Uterine Leiomyosarcoma.
PLoS One. 2015; 10(8):e0133838-e0133838
Doi: 10.1371/journal.pone.0133838
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- Co-authors Med Uni Graz
- Petru Edgar
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- Abstract:
- C-reactive protein (CRP) has previously been shown to serve as a prognostic parameter in women with gynecologic malignancies. Due to the lack of valid prognostic markers for uterine leiomyosarcoma (ULMS) this study set out to investigate the value of pre-treatment CRP serum levels as prognostic parameter. Data of women with ULMS were extracted from databases of three Austrian centres for gynaecologic oncology. Pre-treatment CRP serum levels were measured and correlated with clinico-pathological parameters. Univariate and multivariable survival analyses were performed. In total, 53 patients with ULMS were included into the analysis. Mean (SD) CRP serum level was 3.46 mg/dL (3.96). Solely, an association between pre-treatment CRP serum levels and tumor size (p = 0.04) but no other clinic-pathologic parameter such as tumor stage (p = 0.16), or histological grade (p = 0.07), was observed. Univariate and multivariable survival analyses revealed that CRP serum levels (HR 2.7 [1.1-7.2], p = 0.037) and tumor stage (HR 6.1 [1.9-19.5], p = 0.002) were the only independent prognostic factors for overall survival (OS) in patients with ULMS. Patients with high pre-treatment CRP serum levels showed impaired OS compared to women with low levels (5-year-OS rates: 22.6% and 52.3%, p = 0.007). High pre-treatment CRP serum levels were independently associated with impaired prognosis in women with ULMS and might serve as a prognostic parameter in these patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers, Tumor - blood
- C-Reactive Protein - analysis
- Female -
- Humans -
- Leiomyosarcoma - diagnosis
- Leiomyosarcoma - mortality
- Leiomyosarcoma - pathology
- Middle Aged -
- Neoplasm Staging -
- Prognosis -
- Proportional Hazards Models -
- Survival Rate -
- Uterine Neoplasms - diagnosis
- Uterine Neoplasms - mortality
- Uterine Neoplasms - pathology