Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Køllgaard, T; Ugurel-Becker, S; Idorn, M; Andersen, MH; Becker, JC; Straten, PT.
Pre-Vaccination Frequencies of Th17 Cells Correlate with Vaccine-Induced T-Cell Responses to Survivin-Derived Peptide Epitopes.
PLoS One. 2015; 10(7):e0131934-e0131934
Doi: 10.1371/journal.pone.0131934
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- Co-authors Med Uni Graz
- Becker Jürgen Christian
- Ugurel-Becker Selma
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- Abstract:
- Various subsets of immune regulatory cells are suggested to influence the outcome of therapeutic antigen-specific anti-tumor vaccinations. We performed an exploratory analysis of a possible correlation of pre-vaccination Th17 cells, MDSCs, and Tregs with both vaccination-induced T-cell responses as well as clinical outcome in metastatic melanoma patients vaccinated with survivin-derived peptides. Notably, we observed dysfunctional Th1 and cytotoxic T cells, i.e. down-regulation of the CD3ζchain (p=0.001) and an impaired IFNγ-production (p=0.001) in patients compared to healthy donors, suggesting an altered activity of immune regulatory cells. Moreover, the frequencies of Th17 cells (p=0.03) and Tregs (p=0.02) were elevated as compared to healthy donors. IL-17-secreting CD4+ T cells displayed an impact on the immunological and clinical effects of vaccination: Patients characterized by high frequencies of Th17 cells at pre-vaccination were more likely to develop survivin-specific T-cell reactivity post-vaccination (p=0.03). Furthermore, the frequency of Th17 (p=0.09) and Th17/IFNγ+ (p=0.19) cells associated with patient survival after vaccination. In summary, our explorative, hypothesis-generating study demonstrated that immune regulatory cells, in particular Th17 cells, play a relevant role for generation of the vaccine-induced anti-tumor immunity in cancer patients, hence warranting further investigation to test for validity as predictive biomarkers.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD3 - metabolism
- CD4-Positive T-Lymphocytes - cytology
- Cancer Vaccines - immunology
- Epitopes - immunology
- Humans -
- Inhibitor of Apoptosis Proteins - chemistry
- Interferon-gamma - metabolism
- Interleukin-17 - metabolism
- Kaplan-Meier Estimate -
- Leukocytes, Mononuclear - cytology
- Melanoma - immunology
- Middle Aged -
- Neoplasm Staging -
- Peptides - chemistry
- Prospective Studies -
- T-Lymphocytes, Regulatory - cytology
- Th17 Cells - cytology
- Vaccination -