Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Treiber, G; Prietl, B; Fröhlich-Reiterer, E; Lechner, E; Ribitsch, A; Fritsch, M; Rami-Merhar, B; Steigleder-Schweiger, C; Graninger, W; Borkenstein, M; Pieber, TR.
Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus - A randomized clinical trial.
Clin Immunol. 2015; 161(2):217-224
Doi: 10.1016/j.clim.2015.08.002
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Treiber Gerlies
- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- Fröhlich-Reiterer Elke
- Graninger Winfried
- Pieber Thomas
- Prietl Barbara
- Ribitsch Anja
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- Abstract:
- It is unknown if cholecalciferol is able to modify defects in regulatory T cells (Tregs) in type 1 diabetes (T1D). In this randomized, double-blind, placebo controlled trial 30 young patients with new-onset T1D were assigned to cholecalciferol (70IU/kgbodyweight/day) or placebo for 12months. Tregs were determined by FACS-analysis and functional tests were assessed with ex vivo suppression co-cultures at months 0, 3, 6 and 12. Suppressive capacity of Tregs increased (p<0.001) with cholecalciferol from baseline (-1.59±25.6%) to 3 (30.5±39.4%), 6 (44.6±23.8%) and 12months (37.2±25.0%) and change of suppression capacity from baseline to 12months was significantly higher (p<0.05) with cholecalciferol (22.2±47.2%) than placebo (-16.6±21.1%). Serum calcium and parathormone stayed within normal range. This is the first study, which showed that cholecalciferol improved suppressor function of Tregs in patients with T1D and vitamin D could serve as one possible agent in the development of immunomodulatory combination therapies for T1D. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- C-Peptide - blood
- Child -
- Cholecalciferol - administration & dosage
- Cholecalciferol - blood
- Cholecalciferol - therapeutic use
- Diabetes Mellitus, Type 1 - blood
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - immunology
- Dietary Supplements -
- Double-Blind Method -
- Fasting - blood
- Female -
- Humans -
- Male -
- Pilot Projects -
- Prospective Studies -
- T-Lymphocytes, Regulatory - drug effects
- T-Lymphocytes, Regulatory - immunology
- Time Factors -
- Treatment Outcome -
- Vitamins - administration & dosage
- Vitamins - therapeutic use
- Find related publications in this database (Keywords)
- Type 1 diabetes
- Regulatory T cells
- Suppressive capacity
- Vitamin D
- Cholecalciferol
- Randomized controlled trial