Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aigner, B; Kornprat, P; Schöllnast, H; Kasparek, AK; Mischinger, HJ; Haybaeck, J.
A Case of Focal Small-cell Neuroendocrine Carcinoma in the Vicinity of the Extrahepatic Bile Duct, Adjacent to an Extensive Biliary Intraepithelial Neoplasm: A Diagnostic Challenge with Major Clinical Implications.
Anticancer Res. 2015; 35(9):4821-4828
(- Case Report)
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
- Sadoghi Birgit
- Co-Autor*innen der Med Uni Graz
- Kasparek Anne-Katrin
- Kornprat Peter
- Mischinger Hans-Jörg
- Schoellnast Helmut
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- Abstract:
- Gastroenteropancreatic neuroendocrine tumors are known for their aggressiveness. Diagnosis of various bile duct pathologies, like biliar intraepithelial neoplasm, mixed adenoneuroendocrine carcinomas or small cell carcinomas, is challenging. This case report focuses on a rare case of a focal primary minute small cell carcinoma in the vicinity of the extrahepatic bile duct, presenting itself next to an extensive biliar intraepithelial neoplasm. This finding led to adjuvant chemotherapy, followed by major surgery. Therapeutic approach was based on CT and MRI scans but most importantly on immunohistochemistry and histological evaluation. Initially CR seemed achievable, but metastases were to be found rapidly. The authors want to underline the fact that major clinical decisions are based on sometimes tiny specimens; as literature shows it is absolutely advisable to use markers to differentiate the dignity of investigated areas. The authors call for keeping collision of tumors in mind and adding KOC staining and using it in a routine manner examining biliary duct lesions. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Bile Duct Neoplasms - diagnosis
- Bile Duct Neoplasms - pathology
- Bile Ducts, Extrahepatic - pathology
- Carcinoma in Situ - diagnosis
- Carcinoma in Situ - pathology
- Humans -
- Intestinal Neoplasms - diagnosis
- Intestinal Neoplasms - pathology
- Liver - pathology
- Male -
- Middle Aged -
- Neoplasm Grading -
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - pathology
- Pancreatic Neoplasms - diagnosis
- Pancreatic Neoplasms - pathology
- Stomach Neoplasms - diagnosis
- Stomach Neoplasms - pathology
- Find related publications in this database (Keywords)
- Neuroendocrine carcinoma
- extrahepatic bile duct
- biliary intraepithelial neoplasia
- chemotherapy