Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gass, A; Rocca, MA; Agosta, F; Ciccarelli, O; Chard, D; Valsasina, P; Brooks, JC; Bischof, A; Eisele, P; Kappos, L; Barkhof, F; Filippi, M; MAGNIMS Study Group.
MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis.
Lancet Neurol. 2015; 14(4): 443-454.
Doi: 10.1016/S1474-4422(14)70294-7
Web of Science
PubMed
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- Study Group Mitglieder der Med Uni Graz:
- Enzinger Christian
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- Abstract:
- The spinal cord is a clinically important site that is affected by pathological changes in most patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI can be difficult. Improvements in MRI provide a major advantage for spinal cord imaging, with better signal-to-noise ratio and improved spatial resolution. Through the use of multiplanar MRI, identification of diffuse and focal changes in the whole spinal cord is now routinely possible. Corroborated by related histopathological analyses, several new techniques, such as magnetisation transfer, diffusion tension imaging, functional MRI, and proton magnetic resonance spectroscopy, can detect non-focal, spinal cord pathological changes in patients with multiple sclerosis. Additionally, functional MRI can reveal changes in the response pattern to sensory stimulation in patients with multiple sclerosis. Through use of these techniques, findings of cord atrophy, intrinsic cord damage, and adaptation are shown to occur largely independently of focal spinal cord lesion load, which emphasises their relevance in depiction of the true burden of disease. Combinations of magnetisation transfer ratio or diffusion tension imaging indices with cord atrophy markers seem to be the most robust and meaningful biomarkers to monitor disease evolution in early multiple sclerosis. Copyright © 2015 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Atrophy - diagnosis
- Demyelinating Diseases - diagnosis
- Diffusion Tensor Imaging -
- Humans -
- Magnetic Resonance Imaging - methods
- Magnetic Resonance Spectroscopy - methods
- Multiple Sclerosis - diagnosis Multiple Sclerosis - pathology
- Protons - diagnostic use
- Sensitivity and Specificity -
- Spinal Cord - pathology