Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Panotopoulos, J; Posch, F; Funovics, PT; Willegger, M; Scharrer, A; Lamm, W; Brodowicz, T; Windhager, R; Ay, C.
Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma.
J Orthop Res. 2016; 34(3):533-538
Doi: 10.1002/jor.23002
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- Co-Autor*innen der Med Uni Graz
- Posch Florian
- Windhager Reinhard
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- Abstract:
- Low serum albumin levels and impaired kidney function have been associated with decreased survival in patients with a variety of cancer types. In a retrospective cohort study, we analyzed 84 patients with liposarcoma treated at from May 1994 to October 2011. Uni- and multivariable Cox proportional hazard models and competing risk analyses were performed to evaluate the association between putative biomarkers with disease-specific and overall survival. The median age of the study population was 51.7 (range 19.6-83.8) years. In multivariable analysis adjusted for AJCC tumor stage, serum creatinine was highly associated with disease-specific survival (Subdistribution Hazard ratio (SHR) per 1 mg/dl increase = 2.94; 95%CI 1.39-6.23; p = 0.005). High albumin was associated with improved overall and disease-specific survival (Hazard Ratio (HR) per 10 units increase = 0.50; 95%CI 0.26-0.95; p = 0.033 and SHR = 0.64; 95%CI 0.42-1.00; p = 0.049). The serum albumin-creatinine-ratio emerged to be associated with both overall and disease-specific survival after adjusting for AJCC tumor stage (HR = 0.95; 95%CI 0.92-0.99; p = 0.011 and SHR = 0.96; 95%CI 0.93-0.99; p = 0.08). Our study provides evidence for a tumor-stage-independent association between higher creatinine and lower albumin with worse disease-specific survival. Low albumin and a high albumin-creatinine-ratio independently predict poor overall survival. Our work identified novel prognostic biomarkers for prognosis of patients with liposarcoma. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Albumins - metabolism
- Albumins - epidemiology
- Creatinine - blood
- Female -
- Humans -
- Liposarcoma - blood
- Liposarcoma - mortality
- Male -
- Middle Aged -
- Retrospective Studies -
- Young Adult -
- Find related publications in this database (Keywords)
- prognostic biomarkers
- liposarcoma
- creatinine
- albumin