Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Maniscalco, I; Toffol, E; Giupponi, G; Conca, A.
The interaction of Rhodiola rosea and antidepressants. A case report].
Neuropsychiatr. 2015; 29(1):36-38
Doi: 10.1007/s40211-014-0124-8
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Giupponi Giancarlo
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- Abstract:
- Rhodiola rosea (Russian Rhodiola/Golden Root) is a high mountain plant from the arctic regions of Europe and Asia which has the active substance phenylpropanoide. It has sedative, anti-depressive, drive-enhancing and stress-modulated properties stimulating the distribution of dopamine and serotonin; in combination with other drugs, an increase of side effects and risk profile has to be expected. A case report is presented in order to illustrate the interaction between Rhodiola rosea and antidepressants. We report the case of a 68-year-old female patient with recurrent moderate depressive disorder with somatic syndrome (ICD-10 F33.11) who developed vegetative syndrome, restlessness feeling and trembling since she began to ingest Rhodiola rosea in addition to paroxetine. Prescribing Rhodiola rosea with paroxetine, pharmacokinetic and -dynamic interactions have to be assumed. The symptoms of the patient can be interpreted as a serotonergic syndrome. Because of its different effects, the plant is widely used. An increase of clinical relevant risks should be considered in the add-on treatments.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Depressive Disorder - diagnosis Depressive Disorder - drug therapy Depressive Disorder - psychology
- Female -
- Herb-Drug Interactions -
- Humans -
- Paroxetine - adverse effects Paroxetine - therapeutic use
- Phytotherapy -
- Plant Extracts - adverse effects Plant Extracts - therapeutic use
- Rhodiola -
- Self Medication -
- Serotonin Syndrome - chemically induced Serotonin Syndrome - diagnosis Serotonin Syndrome - psychology
- Somatoform Disorders - diagnosis Somatoform Disorders - drug therapy Somatoform Disorders - psychology
- Find related publications in this database (Keywords)
- Rhodiola rosea
- Russian Rhodiola
- Depressive episode
- Paroxetine
- Drug-drug interaction
- Serotonergic syndrom