Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fridrik, MA; Hausmaninger, H; Linkesch, W; Greil, R; Krieger, O; Baldinger, C; Klocker, J; Pont, J; Oberaigner, W.
Long-term results of dose density therapy in patients with aggressive lymphoma.
ANN HEMATOL. 2005; 84(4): 217-222.
Doi: 10.1007/s00277-004-0936-x
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- To evaluate the long-term outcome of dose density chemotherapy in the treatment of aggressive lymphoma, we analyzed 142 patients with untreated aggressive lymphoma. Chemotherapy was an eight-drug regimen given in weekly intervals in two prospective trials. The median observation period was 8 years; the longest follow-up was 13 years. Overall survival at 8 years was 0.583. The 8-year survival of patients < or =60 years was significantly better than that of older patients, namely 0.713 vs 0.304 (p=0.000000697). This excellent survival of patients aged < or =60 years was identical for high-risk and high-intermediate-risk patients compared with low-risk and low-intermediate-risk patients in the age-adjusted international prognostic index (IPI). The excellent long-term results of the CEOP/IMVP-Dexa regimen (cyclophosphamide, epirubicin, vincristine, and prednisone/ifosfamide with systemic mesna, methotrexate, etoposide, and dexamethasone) for patients aged < or =60 years suggest that this regimen might be superior to the standard CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisolone) and needs to be tested in comparison to high-dose regimens and novel approaches including antibody treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - administration and dosage
- Cause of Death - administration and dosage
- Cyclophosphamide - administration and dosage
- Dexamethasone - administration and dosage
- Epirubicin - administration and dosage
- Etoposide - administration and dosage
- Humans - administration and dosage
- Ifosfamide - administration and dosage
- Longitudinal Studies - administration and dosage
- Lymphoma - drug therapy
- Mesna - administration and dosage
- Methotrexate - administration and dosage
- Middle Aged - administration and dosage
- Prednisone - administration and dosage
- Survival Analysis - administration and dosage
- Treatment Failure - administration and dosage
- Treatment Outcome - administration and dosage
- Vincristine - administration and dosage
- Find related publications in this database (Keywords)
- lymphoma
- large-cell lymphoma
- drug therapy
- antineoplastic combined chemotherapy protocols