Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Socolov, R; Ebner, T; Gorduza, V; Martiniuc, V; Angioni, S; Socolov, D.
Self-oocyte activation and parthenogenesis: an unusual outcome of a misconducted IVF cycle.
Gynecol Endocrinol. 2015; 31(7):529-530
Doi: 10.3109/09513590.2015.1062861
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Ebner Thomas
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- Abstract:
- A rare cause of infertility is the lack of fertilisation with the spontaneous activation of oocytes, leading to parthenogenesis. We present such a case. The patient was a G1P0 38-year-old woman of African ethnicity, who requested an in vitro fertilisation (IVF) with donor sperm. She received a stimulation protocol of 75 IU of FSH/LH from day 3 of the cycle, which she interrupted after 2 d, and restarted with the same dosage for another 3 d from day 7, plus one administration of GnRH antagonist in day 10 of the cycle. With a follicle reaching 19 mm on day 11, estradiol of 325 ng/ml, ovulation was induced with hMG 5000 UI, and oocyte pick-up performed at 30 h. One oocyte was retrieved, and good-quality sperms were added to the insemination procedure. No fecundation occurred at 20 h, with the extruded oocyte separated from the granulosa wall. At 40 h and 64 h the aspect was of three cells, one cell with one nucleus, the others with high granulation and no visible nuclei. This case shows an unusual self-activation oocyte in a poorly managed IVF cycle. The patient will be further evaluated, to decide if a better managed stimulation protocol would prevent recurrence.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Fertilization in Vitro -
- Humans -
- Oocytes -
- Ovulation Induction -
- Parthenogenesis - physiology
- Treatment Failure -
- Find related publications in this database (Keywords)
- Incorrect hormonal treatment
- IVF failure
- oocyte self-activation
- parthenogenesis