Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ebner, T; Maurer, M; Oppelt, P; Mayer, RB; Duba, HC; Costamoling, W; Shebl, O.
Healthy twin live-birth after ionophore treatment in a case of theophylline-resistant Kartagener syndrome.
J Assist Reprod Genet. 2015; 32(6):873-877
Doi: 10.1007/s10815-015-0486-2
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Ebner Thomas
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- Abstract:
- To evaluate whether it is a feasible option to target the oocyte (with Ca(2+)-ionophore) in case that sperm motility cannot be restored in Kartagener syndrome. A case of a male Kartagener syndrome with exclusively immotile spermatozoa that did not react to the dimethylxanthine theophylline. Thus, half of the associated oocytes were treated for 15 min with the ready-to-use- ionophore CultActive immediately after ICSI whereas the other 50 % were injected with routine ICSI without artificial oocyte activation. Rates of fertilization, blastulation, pregnancy and live birth were evaluated. Fertilization check revealed that none of the conventionally injected but 4/6 (66.7 %) of the artificially activated oocytes showed two pronuclei. Three embryos were of good and one of fair quality. Corresponding blastocyst formation rate was 3 out of 4 (75 %). A double embryo transfer led to a healthy twin birth in the 34th week of gestation (two boys with a birth weight of 1724 g and 2199 g). This case indicates that Ca(2+)-ionophore treatment in cycles from theophylline-resistant Kartagener syndrome patients is a feasible option. The future will show if routine application of A23187 in Kartagener or primary cilia dyskinesis patients will be of benefit.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Calcium Ionophores - pharmacology
- Female -
- Humans -
- Infertility, Male - genetics
- Infertility, Male - therapy
- Kartagener Syndrome - complications
- Kartagener Syndrome - genetics
- Live Birth -
- Male -
- Pregnancy -
- Pregnancy, Twin -
- Sperm Injections, Intracytoplasmic -
- Sperm Motility - drug effects
- Theophylline - pharmacology
- Find related publications in this database (Keywords)
- Ca2+-ionophore
- Kartagener syndrome
- Live birth
- Primary cilia dyskinesis
- Twin pregnancy