Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Urban, C; Benesch, M; Sykora, KW; Schwinger, W; Lackner, H.
Non-radiotherapy conditioning with stem cell transplantation from alternative donors in children with refractory severe aplastic anemia.
BONE MARROW TRANSPLANT. 2005; 35(6): 591-594.
Doi: 10.1038/sj.bmt.1704792
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Urban Ernst-Christian
- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Schwinger Wolfgang
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- Abstract:
- Conditioning including total body/lymphoid irradiation is widely used to prevent graft rejection in patients with refractory severe aplastic anemia (SAA) undergoing hemopoietic cell transplantation (HCT) from alternative donors and or after graft manipulation. To reduce regimen-related toxicity we transplanted three children with refractory SAA after conditioning with radiotherapy-free regimens. Conditioning included fludarabine 175-180 mg/m2 in all patients. In addition, patient 1 (failing two previous grafts) received thiotepa 10 mg/kg and Campath-1H 60 mg/m2; patient 2 cyclophosphamide 120 mg/kg, thiotepa 15 mg/kg and OKT-3 0.1 mg/kg/day for 4 weeks; and patient 3 cyclophosphamide 120 and ATG 90 mg/kg. Stem cell source was unmanipulated marrow from the same unrelated donor as for the two previous transplantations in patient 1 and CD34+-purified peripheral blood stem cells from an HLA-matched unrelated donor and from the haploidentical mother in patients 2 and 3. Only patient 1 received graft-versus-host disease (GVHD) prophylaxis with cyclosporine A and mycophenolate mofetil. Follow-up is now 30, 51, and 15 months. None of the patients developed GVHD. All patients have normal counts with complete donor chimerism. Fludarabine-based conditioning is powerfully immunosuppressive and may be used for children with refractory SAA undergoing HCT from alternative donors even after rejection following previous HCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Aplastic - therapy
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Child - therapeutic use
- Child, Preschool - therapeutic use
- Female - therapeutic use
- Graft Survival - therapeutic use
- Hematopoietic Stem Cell Transplantation - methods
- Humans - methods
- Immunosuppressive Agents - therapeutic use
- Male - therapeutic use
- Salvage Therapy - methods
- Tissue Donors - methods
- Transplantation Conditioning - methods
- Transplantation, Homologous - methods
- Vidarabine - administration and dosage
- Find related publications in this database (Keywords)
- severe aplastic anemia
- transplantation
- non-radiotherapy conditioning