Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Teubl, BJ; Schimpel, C; Leitinger, G; Bauer, B; Fröhlich, E; Zimmer, A; Roblegg, E.
Interactions between nano-TiO2 and the oral cavity: impact of nanomaterial surface hydrophilicity/hydrophobicity.
J Hazard Mater. 2015; 286(12):298-305
Doi: 10.1016/j.jhazmat.2014.12.064
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fröhlich Eleonore
- Leitinger Gerd
- Schimpel Christa
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- Abstract:
- Titanium dioxide (TiO2) nanoparticles are available in a variety of oral applications, such as food additives and cosmetic products. Thus, questions about their potential impact on the oro-gastrointestinal route rise. The oral cavity represents the first portal of entry and is known to rapidly interact with nanoparticles. Surface charge and size contribute actively to the particle-cell interactions, but the influence of surface hydrophilicity/hydrophobicity has never been shown before. This study addresses the biological impact of hydrophilic (NM 103, rutile, 20 nm) and hydrophobic (NM 104, rutile, 20 nm) TiO2 particles within the buccal mucosa. Particle characterization was addressed with dynamic light scattering and laser diffraction. Despite a high agglomeration tendency, 10% of the particles/agglomerates were present in the nanosized range and penetrated into the mucosa, independent of the surface properties. However, significant differences were observed in intracellular particle localization. NM 104 particles were found freely distributed in the cytoplasm, whereas their hydrophobic counterparts were engulfed in vesicular structures. Although cell viability/membrane integrity was not affected negatively, screening assays demonstrated that NM 104 particles showed a higher potential to decrease the physiological mitochondrial membrane potential than NM 103, resulting in a pronounced generation of reactive oxygen species. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Line -
- Cell Survival - drug effects
- Cricetulus -
- Hydrophobic and Hydrophilic Interactions -
- In Vitro Techniques -
- Lysosomes - drug effects
- Lysosomes - metabolism
- Lysosomes - ultrastructure
- Membrane Potential, Mitochondrial - drug effects
- Mitochondria - drug effects
- Mitochondria - metabolism
- Mitochondria - ultrastructure
- Mouth Mucosa - drug effects
- Mouth Mucosa - metabolism
- Mouth Mucosa - ultrastructure
- Nanoparticles - chemistry
- Particle Size -
- Permeability -
- Reactive Oxygen Species - metabolism
- Surface Properties -
- Swine -
- Titanium - chemistry
- Titanium - pharmacokinetics
- Titanium - toxicity
- Find related publications in this database (Keywords)
- Titanium dioxide nanoparticles
- Hydrophilicity/hydrophobicity
- Oral cavity
- Intracellular distribution
- Toxicity