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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sikiric, P; Seiwerth, S; Rucman, R; Turkovic, B; Rokotov, DS; Brcic, L; Sever, M; Klicek, R; Radic, B; Drmic, D; Ilic, S; Kolenc, D; Aralica, G; Safic, H; Suran, J; Rak, D; Dzidic, S; Vrcic, H; Sebecic, B.
Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.
Curr Pharm Des. 2013; 19(1): 76-83.
Doi: 10.2174/1381612811306010076
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- Brcic Luka
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- Abstract:
- Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157 beneficial effects on stomach, duodenum, intestine, liver and brain injuries, adjuvant arthritis, pain, hyper/hypothermia, obstructive thrombus formation and thrombolysis, blood vessel function, counteraction of prolonged bleeding and thrombocytopenia after application of various anticoagulants and antiplatelet agents and wound healing improvement. The arguments for BPC 157 antidote activity (i.e., the role of BPC 157 in cytoprotection, being a novel mediator of Robert's cytoprotection and BPC 157 beneficial effects on NSAIDs mediated lesions in the gastrointestinal tract, liver and brain and finally, counteraction of aspirin-induced prolonged bleeding and thrombocytopenia) obviously have a counteracting effect on several established side-effects of NSAIDs use. The mentioned variety of the beneficial effects portrayed by BPC 157 may well be a foundation for establishing BPC 157 as a NSAIDs antidote since no other single agent has portrayed a similar array of effects. Unlike NSAIDs, a very high safety (no reported toxicity (LD1 could be not achieved)) profile is reported for BPC 157. Also, unlike the different dosage levels of aspirin, as a NSAIDs prototype, which differ by a factor of about ten, all these beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage (μg, ng/kg) in parenteral or peroral regimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents, Non-Steroidal - adverse effects
- Anti-Ulcer Agents - adverse effects Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use
- Antidotes - adverse effects Antidotes - pharmacology Antidotes - therapeutic use
- Aspirin - adverse effects
- Brain - drug effects Brain - physiopathology
- Gastrointestinal Tract - drug effects Gastrointestinal Tract - physiopathology
- Humans -
- Liver - drug effects Liver - physiopathology
- Peptide Fragments - adverse effects Peptide Fragments - pharmacology Peptide Fragments - therapeutic use
- Proteins - adverse effects Proteins - pharmacology Proteins - therapeutic use
- Find related publications in this database (Keywords)
- NSAIDs-gastrointestinal tract lesions
- NSAIDs-liver lesions
- NSAIDs-brain lesions
- aspirin-prolonged bleeding/ thrombocytopenia
- stable gastric pentadecapeptide BPC 157
- counteraction
- antidote against NSAIDs