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SHR Neuro Cancer Cardio Lipid Metab Microb
Brcic, L; Sherer, CK; Shuai, Y; Hornick, JL; Chirieac, LR; Dacic, S.
Morphologic and clinicopathologic features of lung squamous cell carcinomas expressing Sox2.
Am J Clin Pathol. 2012; 138(5): 712-718.
Doi: 10.1309/AJCP05TTWQTWNLTN
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- Brcic Luka
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- Abstract:
- Sox2 amplification was recently reported as a common event in squamous cell carcinomas (SCCs) occurring at different anatomic sites including the lung. The objective of the study was to determine morphologic and clinicopathologic characteristics of lung SCCs with respect to Sox2 protein expression and gene amplification. One hundred forty-seven surgically treated non-small cell lung carcinomas were analyzed for Sox2 gene amplification by using fluorescence in situ hybridization and protein expression using immunohistochemical analysis. SCC showed more frequent Sox2 protein expression (52/66; 79%) than adenocarcinomas (ADC) (14/76; 18%) (P < .0001). Similarly, Sox2 amplification was more frequent in SCCs (52/70; 72%) than in ADCs (6/77; 8%) (P < .0001). Sox2 protein expression was associated with better overall survival in SCC (66 vs 14 months; P =.048). SCC with basaloid differentiation and severe nuclear atypia exhibited more intense Sox2 protein expression than other tumors. Sox2 appears to be an important gene in lung squamous cell carcinogenesis that in particular drives the development of poorly differentiated tumors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology
- Female -
- Gene Amplification -
- Gene Dosage -
- Humans -
- Lung - metabolism Lung - pathology
- Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology
- Male -
- Middle Aged -
- Prognosis -
- SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism
- Survival Rate -
- Find related publications in this database (Keywords)
- Lung squamous cell carcinoma
- Sox2 amplification
- Protein expression
- Morphology
- Prognosis