Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hrelec, M; Klicek, R; Brcic, L; Brcic, I; Cvjetko, I; Seiwerth, S; Sikiric, P.
Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy.
J Physiol Pharmacol. 2009; 60 Suppl 7(4): 161-165.
Web of Science
PubMed
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- Abstract:
- We focused on abdominal aorta, clamped and transected bellow renal arteries, and aortic termino-terminal anastomosis created in Albino male rats. We suggested stomach cytoprotection theory holding endothelium protection and peptidergic anti-ulcer cytoprotection therapy to improve management of abdominal aorta anastomosis and thrombus formation. The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419) is a small anti-ulcer peptide efficient in inflammatory bowel disease trials (PL 14736) and various wound treatment, no toxicity reported. After 24 h following aortic termino-terminal anastomosis, we shown that BPC 157 (10 microg/kg) may also decrease formation of cloth after aortic termino-terminal anastomosis and preserved walking ability and muscle strength when given as a bath immediately after aortic anastomosis creation. This may be important since aortic termino-terminal anastomosis is normally presenting in rats with a formed cloth obstructing more than third of aortic lumen, severely impaired walking ability, painful screaming and weak muscle strength. Thereby, the effect of BPC 157 (10 microg/kg) was additionally studied at 24 h following aortic termino-terminal anastomosis. Given at the that point, intraperitoneally, within 3 minutes post-application interval the pentadecapeptide BPC 157 rapidly recovered the function of lower limbs and muscle strength while no cloth could be seen in those rats at the anastomosis site.
- Find related publications in this database (using NLM MeSH Indexing)
- Anastomosis, Surgical - rehabilitation
- Animals -
- Aorta, Abdominal - pathology Aorta, Abdominal - surgery
- Drug Administration Routes -
- Endothelium, Vascular - injuries
- Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use
- Hindlimb -
- Intraoperative Care - methods
- Male -
- Muscle Strength - drug effects
- Pain, Postoperative - drug therapy
- Paresis - drug therapy Paresis - etiology Paresis - prevention & control
- Peptide Fragments - administration & dosage Peptide Fragments - therapeutic use
- Postoperative Complications - prevention & control
- Proteins - administration & dosage Proteins - therapeutic use
- Random Allocation -
- Rats -
- Rats, Wistar -
- Severity of Illness Index -
- Thrombosis - complications Thrombosis - drug therapy Thrombosis - pathology Thrombosis - prevention & control
- Time Factors -
- Vascular Diseases - drug therapy
- Walking -
- Find related publications in this database (Keywords)
- abdominal aorta anastomosis
- thrombus
- stable gastric pentadecapeptide BPC 157
- inflammatory bowel disease