Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Novinscak, T; Brcic, L; Staresinic, M; Jukic, I; Radic, B; Pevec, D; Mise, S; Tomasovic, S; Brcic, I; Banic, T; Jakir, A; Buljat, G; Anic, T; Zoricic, I; Romic, Z; Seiwerth, S; Sikiric, P.
Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.
Surg Today. 2008; 38(8): 716-725.
Doi: 10.1007/s00595-007-3706-2
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- Brcic Iva
- Brcic Luka
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- Abstract:
- Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported. In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days. BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase). BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.
- Find related publications in this database (using NLM MeSH Indexing)
- Achilles Tendon - drug effects Achilles Tendon - injuries Achilles Tendon - physiopathology
- Animals -
- Male -
- Peptide Fragments - pharmacology
- Proteins - pharmacology
- Random Allocation -
- Rats -
- Rats, Wistar -
- Recovery of Function -
- Statistics, Nonparametric -
- Stress, Mechanical -
- Tendon Injuries - drug therapy Tendon Injuries - physiopathology
- Wound Healing - drug effects Wound Healing - physiology
- Find related publications in this database (Keywords)
- BPC 157
- crush injury
- peptide therapy
- muscle regeneration
- rat