Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brcić, L; Vuletić, LB; Stepan, J; Bonevski, A; Jakovljević, G; Gasparov, S; Marjanović, K; Seiwerth, S.
Mast-cell sarcoma of the tibia.
J Clin Pathol. 2007; 60(4): 424-425.
Doi: 10.1136/jcp.2006.040857
(- Case Report)
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- Abstract:
- The mast-cell sarcoma of a bone is described here for the first time. The tumour presented in a 4-year-old boy, with pain, oedema and deformation of his right lower leg. Radiological findings revealed a destructive tumourous mass. Histopathological examination showed the tumour to be composed of large, atypical cells, with hyperchromatic oval and polygonal nuclei. The cytoplasm around them was eosinophilic with many basophilic and toluidine-blue-positive granules. These atypical mast cells were positive for chloroacetate esterase, c-kit, tryptase and negative for myeloperoxidase. The primary disease quickly progressed to mast-cell leukaemia, and despite intensive chemotherapy the patient died 18 months after first symptoms.
- Find related publications in this database (using NLM MeSH Indexing)
- Bone Neoplasms - pathology Bone Neoplasms - radiography
- Child, Preschool -
- Disease Progression -
- Fatal Outcome -
- Humans -
- Male -
- Mast-Cell Sarcoma - pathology Mast-Cell Sarcoma - radiography
- Tibia -
- Tomography, X-Ray Computed -