Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vuksic, T; Zoricic, I; Brcic, L; Sever, M; Klicek, R; Radic, B; Cesarec, V; Berkopic, L; Keller, N; Blagaic, AB; Kokic, N; Jelic, I; Geber, J; Anic, T; Seiwerth, S; Sikiric, P.
Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.
Surg Today. 2007; 37(9): 768-777.
Doi: 10.1007/s00595-006-3498-9
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PubMed
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- Abstract:
- Gastric pentadecapeptide BPC 157 (BPC 157), which has been shown to be safe in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia), may be able to cure intestinal anastomosis dehiscence. This antiulcer peptide shows no toxicity, is limit test negative, and a lethal dose is not achieved. It is stable in human gastric juice. In comparison with other standard treatments it is more effective for ulcers and various wounds, and can be used without a carrier needed for other peptides, both locally and systemically (i.e., perorally, parenterally). We studied the effectiveness of BPC 157 for ileoileal anastomosis healing in rats. We assessed ileoileal anastomosis dehiscence macroscopically, histologically, and biomechanically (volume [ml] infused through a syringe-perfusion pump system (1 ml/10 s), and pressure [mmHg] to leak induction [catheter connected to a chamber and a monitor, at 10 cm proximal to anastomosis]), at 1, 2, 3, 4, 5, 6, 7, and 14 days. BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice. Throughout the experiment, both higher doses of BPC 157 were shown to improve all parameters of anastomotic wound healing. The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed. Anastomosis without leakage induces markedly higher volume and pressure values, with a continuous increase toward healthy values. From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization. This study showed BPC 157 to have a beneficial effect on ileoileal anastomosis healing in the rat.
- Find related publications in this database (using NLM MeSH Indexing)
- Anastomosis, Surgical -
- Animals -
- Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use
- Collagen - drug effects
- Collagen -
- Epithelium - drug effects
- Ileus - surgery
- Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - surgery
- Male -
- Peptide Fragments - pharmacology Peptide Fragments - therapeutic use
- Proteins - pharmacology Proteins - therapeutic use
- Rats -
- Rats, Wistar -
- Tissue Adhesions -
- Wound Healing - drug effects
- Find related publications in this database (Keywords)
- pentadecapeptide BPC 157
- ileoileal anastomosis healing
- rat