Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ilic, S; Drmic, D; Zarkovic, K; Kolenc, D; Brcic, L; Radic, B; Djuzel, V; Blagaic, AB; Romic, Z; Dzidic, S; Kalogjera, L; Seiwerth, S; Sikiric, P.
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats.
Eur J Pharmacol. 2011; 667(1-3): 322-329.
Doi: 10.1016/j.ejphar.2011.05.038
Web of Science
PubMed
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- Abstract:
- Chronic ibuprofen (0.4 g/kg intraperitoneally, once daily for 4 weeks) evidenced a series of pathologies, not previously reported in ibuprofen-dosed rats, namely hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values with prolonged sedation/unconsciousness, and weight loss. In particular, ibuprofen toxicity was brain edema, particularly in the cerebellum, with the white matter being more affected than in gray matter. In addition, damaged and red neurons, in the absence of anti-inflammatory reaction was observed, particularly in the cerebral cortex and cerebellar nuclei, but was also present although to a lesser extent in the hippocampus, dentate nucleus and Purkinje cells. An anti-ulcer peptide shown to have no toxicity, the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10 μg, 10 ng/kg) inhibited the pathology seen with ibuprofen (i) when given intraperitoneally, immediately after ibuprofen daily or (ii) when given in drinking water (0.16 μg, 0.16 ng/ml). Counteracted were all adverse effects, such as hepatic encephalopathy, the gastric lesions, hepatomegaly, increased liver serum values. In addition, BPC 157 treated rats showed no behavioral disturbances and maintained normal weight gain. Thus, apart from efficacy in inflammatory bowel disease and various wound treatments, BPC 157 was also effective when given after ibuprofen. Copyright © 2011 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Animals -
- Anti-Ulcer Agents - adverse effects Anti-Ulcer Agents - pharmacology
- Behavior, Animal - drug effects
- Brain - drug effects Brain - pathology
- Brain Injuries - chemically induced
- Hepatic Encephalopathy - chemically induced Hepatic Encephalopathy - pathology Hepatic Encephalopathy - prevention & control
- Hepatomegaly - chemically induced Hepatomegaly - pathology Hepatomegaly - prevention & control
- Ibuprofen - adverse effects Ibuprofen - antagonists & inhibitors
- Liver - drug effects Liver - enzymology Liver - pathology
- Male -
- Molecular Sequence Data -
- Organ Size - drug effects
- Peptides - adverse effects Peptides - chemistry Peptides - pharmacology
- Rats -
- Rats, Wistar -
- Stomach - drug effects Stomach - injuries Stomach - metabolism Stomach - pathology
- Stomach Diseases - chemically induced Stomach Diseases - pathology Stomach Diseases - prevention & control
- Find related publications in this database (Keywords)
- Ibuprofen
- Hepatic encephalopathy
- Hepatomegaly
- Sedation/unconsciousness
- Gastric lesion
- Pentadecapeptide BPC 157
- Rat