Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sukara, G; Baresic, M; Sentic, M; Brcic, L; Anic, B.
Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature.
Acta Reumatol Port. 2015; 40(2):169-175
(- Case Report)
[OPEN ACCESS]
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Brcic Luka
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- Abstract:
- Catastrophic antiphospholipid syndrome (CAPS) is a rare, acute, life-threatening form of antiphospholipid syndrome. In the last several decades there has been a significant improvement in the treatment of patients with CAPS, but the overall mortality is still very significant. The use of rituximab has been reported in the treatment of refractory cases of CAPS but the data are still scarce and inconclusive. We report a case of 47-year old male patient with long standing SLE and secondary APS who presented with acute thromboembolic incident (partial thrombosis of superior mesenteric artery). During the first week of his hospitalization he met the criteria for probable CAPS. He was treated with anticoagulants, glucocorticoids, intravenous immunoglobulins and systemic antibiotics. Finally he was treated with rituximab. There was no response to the implemented treatment and he eventually died. Autopsy showed evidence of small vessel thrombosis in the lung microvasculature. With this the criteria for definitive CAPS were fulfilled. To our knowledge, at present time, this is the first ever reported case of definitive CAPS associated with SLE treated with rituximab. There is a great need for further investigation to evaluate the effectiveness of rituximab in treatment of CAPS.
- Find related publications in this database (using NLM MeSH Indexing)
- Antiphospholipid Syndrome - complications
- Antiphospholipid Syndrome - drug therapy
- Humans -
- Immunologic Factors - therapeutic use
- Lupus Erythematosus, Systemic - complications
- Male -
- Middle Aged -
- Rituximab - therapeutic use
- Find related publications in this database (Keywords)
- Systemic Lupus Erythematosus
- Rituximab
- Antiphospholipid Syndrome