Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Duplancic, B; Stambolija, V; Holjevac, J; Zemba, M; Balenovic, I; Drmic, D; Suran, J; Radic, B; Filipovic, M; Blagaic, AB; Brcic, L; Kolenc, D; Grabarevic, Z; Seiwerth, S; Sikiric, P.
Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration.
Eur J Pharmacol. 2014; 727(6): 75-79.
Doi: 10.1016/j.ejphar.2014.01.046
Web of Science
PubMed
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- Abstract:
- Anesthetized mice or rats received intravenously 6%, 10%, 20%, 40%, 60%, 80%, and 90% dextran and/or white egg (1ml/rat or 0.15ml/mouse) into their tails. Medication (/kg b.w., 5ml/kg) was given intraperitoneally (BPC 157 10µg, 1µg, 10ng, and 10pg/kg, chloropyramine 20mg/kg, and cimetidine 10mg/kg intraperitoneally, alone or in combination while controls received an equivolume of saline), immediately after challenge or, alternatively, at 5min after or 24 or 48h before challenge. The effect was assessed at 5, 10, 20 and 30min after dextran and/or white egg challenge. We commonly noted prominent edema involving the face, upper and lower lip, snout, paws and scrotum (presented with extreme cyanosis), poor respiration and the number of fatalities after dextran and/or white egg application. Contrary, BPC 157 regimens (10µg, 1µg, 10ng, and 10pg/kg) effectively, may both prevent anaphylactoid reactions that may arise from dextran and/or white egg application and furthermore, rescue already advanced reactions when given after the challenge. Chloropyramine and cimetidine given alone were only moderately effective. When given together with BPC 157, the observed effect correlates with the strong effect of BPC 157 given alone. Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intravenous -
- Anaphylaxis - chemically induced Anaphylaxis - prevention & control
- Animals -
- Anti-Allergic Agents - pharmacology
- Cimetidine - pharmacology
- Dextrans -
- Disease Models, Animal -
- Edema - chemically induced Edema - prevention & control
- Egg White -
- Ethylenediamines - pharmacology
- Histamine H1 Antagonists - pharmacology
- Histamine H2 Antagonists - pharmacology
- Male -
- Mice -
- Peptide Fragments - pharmacology
- Proteins - pharmacology
- Rats, Wistar -
- Time Factors -
- Find related publications in this database (Keywords)
- Pentadecapeptide BPC 157
- Anaphylactoid reaction
- Dextran
- Ovalbumin